Rosemary Assis

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BACKGROUND Inflammation is a major feature of sickle cell disease (SCD). Low-dose methotrexate (MTX) has long been used in chronic inflammatory diseases. This pilot study examined the MTX effect on acute vaso-occlusive pain crises (VOC) in SCD patients. METHODS Fourteen adults on hydroxyurea with severe and refractory VOC received one intramuscular(More)
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