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On September 14, 2015 at 09:50:45 UTC the two detectors of the Laser Interferometer Gravitational-Wave Observatory simultaneously observed a transient gravitational-wave signal. The signal sweeps upwards in frequency from 35 to 250 Hz with a peak gravitational-wave strain of 1.0×10(-21). It matches the waveform predicted by general relativity for the(More)
BACKGROUND Efficacy trials suggest that structured psychological therapies may significantly reduce recurrence rates of major mood episodes in individuals with bipolar disorders. AIMS To compare the effectiveness of treatment as usual with an additional 22 sessions of cognitive-behavioural therapy (CBT). METHOD We undertook a multicentre, pragmatic,(More)
BACKGROUND Adverse family experiences in early life are associated with subsequent psychopathology. This study adds to the growing body of work exploring the nature and associations between adverse experiences over the childhood years. METHODS Primary carers of 1143 randomly recruited 14-year olds in Cambridgeshire and Suffolk, UK were interviewed using(More)
BACKGROUND Investigations of the structure of psychological well-being items are useful for advancing knowledge of what dimensions define psychological well-being in practice. Ryff has proposed a multidimensional model of psychological well-being and her questionnaire items are widely used but their latent structure and factorial validity remains(More)
BACKGROUND Previous studies indicate that depressed patients with partial remission and residual symptoms following antidepressant treatment are common and have high rates of relapse. There is evidence that cognitive therapy may reduce relapse rates in depression. METHODS One hundred fifty-eight patients with recent major depression, partially remitted(More)
BACKGROUND Long-term studies of severe depression have described high rates of non-recovery, recurrence, chronic incapacity and mortality. A more recent cohort was followed-up to ascertain whether the course had improved given developments in pharmacological and psychological treatments in the last 15 years. METHOD Subjects from a cohort of 70 mainly(More)
BACKGROUND Studies of urban-rural differences in prevalence of non-psychotic mental disorder have not given consistent findings. Such differences have received relatively little study in Great Britain. METHODS Data from 9777 subjects in the Household Survey of the National Morbidity Survey of Great Britain were analysed for differences between urban,(More)
BACKGROUND About 30% of psychiatric out-patients with major depression demonstrate partial remission. AIMS To explore whether the addition of cognitive therapy (CT) had any differential effect on residual symptoms or social adjustment. METHOD Patients with residual symptoms of major depression (n=158) were randomised to receive clinical management (CM)(More)
BACKGROUND Few follow-up studies of depression have evaluated depressive symptomatology over time at both threshold and sub-threshold levels. AIMS To evaluate long-term longitudinal symptomatic course after an episode of severe depression. METHOD A total of 61 participants from a previous study cohort underwent a detailed interview covering the(More)
Sixteen children underwent 18 operations for radical resection of chiasmatic-hypothalamic tumors. The clinical presentation correlated with age: infants under 1 year of age presented with macrocephaly, failure to thrive, and severe visual failure; children aged 1 to 5 years predominantly had precocious puberty with mild visual deficits; and older children(More)