Roselyne Boulieu

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BACKGROUND Polymorphic thiopurine S-methyltransferase (TPMT) is a major determinant of thiopurine toxicity. METHODS We extracted 6-thioguanine nucleotides (6-TGNs) and 6-methylmercaptopurine nucleotides (6-MMPNs) from erythrocytes with perchloric acid and converted them to 6-thioguanine (6-TG) and a 6-methylmercaptopurine (6-MMP) derivative during a(More)
This study aimed at assessing the effects of midazolam (MDZ) sedation on auditory brainstem (BAEP) and middle latency (MLAEP) evoked potentials in intensive care conditions. Ten ventilated comatose patients were receiving an intravenous MDZ bolus dose (0.2 mg/kg) followed by a 2 h continuous infusion (0.1 mg/kg/h). MLAEPs and BAEPs elicited by clicks (90 dB(More)
A simple, fast, precise and sensitive method for the quantification of IR3535 ® , an insect repellent used in topical formulations, was developed by reversed-phase high performance liquid chromatography. The separation was carried out by using a core-shell silica particles column (Kinetex ® C18, 5 m, 4.6 mm x 150 mm) with a mobile phase consisting of 0.1%(More)
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