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The Coffin-Lowry syndrome (CLS) is a syndromic form of intellectual disability caused by loss-of-function of the RSK2 serine/threonine kinase encoded by the rsk2 gene. Rsk2 knockout mice, a murine model of CLS, exhibit spatial learning and memory impairments, yet the underlying neural mechanisms are unknown. In the current study, we examined the performance(More)
The different gene members of the Egr family of transcriptional regulators have often been considered to have related functions in brain, based on their co-expression in many cell-types and structures, the relatively high homology of the translated proteins and their ability to bind to the same consensus DNA binding sequence. Recent research, however,(More)
It is well established that Egr1/zif268, a member of the Egr family of transcription factors, is critical for the consolidation of several forms of memories. Recently, the Egr3 family member has also been implicated in learning and memory. Because Egr family members encode closely related zinc-finger transcription factors sharing a highly homologous DNA(More)
CONTEXT Recent studies and anecdotal reports suggest that binaural auditory beats can affect mood, performance on vigilance tasks, and anxiety. OBJECTIVE To determine whether mildly anxious people would report decreased anxiety after listening daily for 1 month to tapes imbedded with tones that create binaural beats, and whether they would show a definite(More)
The idea that an already consolidated memory can become destabilized after recall and requires a process of reconsolidation to maintain it for subsequent use has gained much credence over the past decade. Experimental studies in rodents have shown pharmacological, genetic, or injurious manipulation at the time of memory reactivation can disrupt the already(More)
Food preferences were investigated in cuttlefish during the first 3 months' posthatching, using choice tests between crabs, shrimps, and young fish. The results showed that without previous feeding experience, cuttlefish preferred shrimps on Day 3. This suggests an innate food preference; however, it was possible to induce a preference for an originally(More)
This study investigates effects of the environment on the maturation of body patterns in cuttlefish (Sepia officinalis). Cuttlefish were reared either individually on a uniform background, which the authors have termed uniform-solitary conditions (Group A), or grouped on variegated backgrounds, which the authors have termed varied-social conditions (Group(More)
Functional and structural plasticity is a fundamental property of the brain involved in diverse processes ranging from brain construction and repair to storage of experiences during lifetime. Our current understanding of different forms of brain plasticity mechanisms has advanced tremendously in the last decades, benefiting from studies of development and(More)
The multifactorial causes impacting the risk of developing sporadic forms of Alzheimer's disease (AD) remain to date poorly understood. Epidemiologic studies in humans and research in rodents have suggested that hypothyroidism could participate in the etiology of AD. Recently, we reported that adult-onset hypothyroidism in rats favors β-amyloid peptide(More)
The inhibition of predatory behavior observed during the "prawn-in-the-tube" procedure has been extensively used in studies of cuttlefish learning. The present study examines the effect of age on the conditioning of this response in the cuttlefish, Sepia officinalis. Data show that a significant increase in acquisition performance occurs between 15 and 21(More)