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  • Vijay Dhawan, David J. Schwalb, +5 authors David R Janero
  • Chemistry, Medicine
  • Free radical biology & medicine
  • 2005 (First Published: 1 November 2005)
  • Nitric oxide (NO) enhances anti-inflammatory drug action. Through a metabonomics approach termed "NObonomics," the effects of a prototypic NO donor (organic nitrate)-cyclooxygenase-2 inhibitor hybridContinue Reading
  • Shiow-Jyi Wey, Michael E. Augustyniak, +16 authors Brian M Zifcak
  • Chemistry, Medicine
  • Journal of medicinal chemistry
  • 2007 (First Published: 1 December 2007)
  • Indomethacin, a nonselective cyclooxygenase (COX) inhibitor, was modified in three distinct regions in an attempt both to increase cyclooxygenase-2 (COX-2) selectivity and to enhance drug safety byContinue Reading
  • Sara Anne Little, Sumathi Chittamuru, Tim Murphy, Roseanne S Wexler, Laxman S. Desai
  • Medicine
  • 2018 (First Published: 20 May 2018)
  • e14509Background: Cyclin dependent kinases (CDK) play a vital role in cell cycling and proliferation. Altered expression of these kinases in malignant cells results in deregulation of cell cycle ac...