Learn More
The case of an infant with Werding-Hoffmann disease, who died at the age of 4 1/2 days, is reported. At autopsy there was severe cerebellar hypoplasia, associated with degenerative changes in the brain-stem nuclei. This case supports the concept that cerebellar hypoplasia may develop as a manifestation of the neuronal abiotrophy of Werdnig-Hoffmann disease.(More)
The neuroleptic malignant syndrome (NMS) is a rare but potentially fatal disorder characterized by mental-status changes, muscle rigidity, hyperthermia, and autonomic dysfunction. Systematic examination of early signs and the progression of symptoms in NMS may be worthwhile to facilitate prompt recognition and interventions to abort the syndrome in its(More)
This study examined electrocardiographic and echocardiographic characteristics of endurance- and resistance-trained female athletes. The subjects were 10 varsity caliber endurance-trained athletes, 10 resistance-trained athletes, and 10 nonathletes. Data collection included anthropometric measurements, VO2max, standard 12-lead ECGs and left ventricular(More)
Echocardiographic dimensions, anthropometric data and maximal oxygen uptake (VO2max) were studied in 26 healthy sedentary male controls (mean age, 22.0 yrs) and 15 male endurance athletes (mean age, 20.3 yrs). Athletes displayed significantly greater mean values for left ventricular internal dimension at end-diastole (LVIDd), end-diastolic volume (LVEDV)(More)
Although the majority of cases of hereditary chorea correspond accurately to the classical pattern described by Huntington (1872), a number of atypical forms have been recorded in children and adults which are characterized by rigidity rather than by hyperkinesia. Most of these have been reported in the continental literature and we thought it was of(More)
Hypoplasia predominantly affecting the lateral lobes of the cerebellum has on several occasions been found associated with marked underdevelopment of the griseum pontis and middle peduncle (Vogt and Astwazaturow, 1912; Brun, 1917, 1918; Brouwer, 1924; Biemond, 1955). Brouwer named this condition " hypoplasia ponto-neocerebellaris " and emphasized the fact(More)
Recent classifications of the diffuse cerebral scleroses have recognized the need to subdivide those cases which share in common the feature of sudanophil breakdown products of myelin. In Schilder's disease, as represented by the case he described in 1912, there are large, bilocular, sharply demarcated areas of demyelination in the centrum ovale, often(More)
Before the advent of effective chemotherapy, pneumococcal meningitis was not only a fatal disease, but one that ran its full course with great rapidity. Cases invariably came to necropsy within 10 days of the onset of the illness and usually very much sooner (Cairns and Russell, 1946). Although sulphonamides alone had little effect on the ultimate mortality(More)