Rose Keeling

  • Citations Per Year
Learn More
Understanding how protein-protein interactions depend on the choice of buffer, salt, ionic strength, and pH is needed to have better control over protein solution behavior. Here, we have characterized the pH and ionic strength dependence of protein-protein interactions in terms of an interaction parameter kD obtained from dynamic light scattering and the(More)
Better predictive ability of salt and buffer effects on protein-protein interactions requires separating out contributions due to ionic screening, protein charge neutralization by ion binding, and salting-in(out) behavior. We have carried out a systematic study by measuring protein-protein interactions for a monoclonal antibody over an ionic strength range(More)
  • P. Di Stefanoa, M. Bruckmayer, +17 authors SAPPHIRE CALORIMETERS
The CRESST experiment seeks hypothetical WIMP particles that could account for the bulk of dark matter in the Universe. The detectors are cryogenic calorimeters in which WIMPs would scatter elastically on nuclei, releasing phonons. The first phase of the experiment has successfully deployed several 262 g sapphire devices in the Gran Sasso underground(More)
Predicting the concentrated solution behavior for monoclonal antibodies requires developing and using minimal models to describe their shape and interaction potential. Toward this end, the small-angle X-ray scattering (SAXS) profiles for a monoclonal antibody (COE-03) have been measured under solution conditions chosen to produce weak self-association. The(More)
  • 1