Rosario Vega

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Lead (Pb2+), a heavy metal, has been used by humans for many technological purposes, which is the main reason for its present widespread distribution. Although various actions have been taken to decrease the use and distribution of lead in the environment, it remains a significant health hazard. The toxic mechanism of lead is caused by its ability to(More)
Limón, Agenor, Cristina Pérez, Rosario Vega, and Enrique Soto. Ca -activated K -current density is correlated with soma size in rat vestibularafferent neurons in culture. J Neurophysiol 94: 3751–3761, 2005. First published August 17, 2005; doi:10.1152/jn.00177.2005. Vestibular-afferent neurons (VANs) transmit information about linear and angular(More)
Vestibular-afferent neurons transmit information about linear and angular accelerations during head movements from vestibular end-organs to vestibular nuclei. In situ, these neurons show heterogeneous discharge patterns that may be produced by differences in their intrinsic properties. However, little is known about the ionic currents underlying their(More)
Several studies have shown that type I hair cells present a large outward rectifying potassium current (g(K,L)) that is substantially activated at the resting potential, greatly reducing cell input resistance and voltage gain. In fact, mechanoelectrical transducer currents seem not to be large enough to depolarize type I hair cells to produce(More)
A Turbo Pascal program for data acquisition and analysis is presented. The program detects incoming data as TTL pulses through the serial port of an IBM-PC and compatible computers and displays the instantaneous frequency plot and the interval histogram on-line. Novel features of this Pascal program are: no special hardware requirements and on-line analysis(More)
There is consensus that muscarinic and nicotinic receptors expressed in vestibular hair cells and afferent neurons are involved in the efferent modulation of the electrical activity of the afferent neurons. However the underlying mechanisms of postsynaptic control in neurons are not well understood. In our work we show that the activation of muscarinic(More)
Conus californicus belongs to a genus of marine gastropods with more than 700 extant species. C. californicus has been shown to be distantly related to all Conus species, but showing unusual biological features. We report a novel peptide isolated from C. californicus with a significant inhibitory action over neuronal voltage-gated calcium channels. The new(More)
This study aimed to define the pharmacology and physiological role of the N-methyl-D-aspartate (NMDA) receptor in the synapse between the hair cells and primary afferent neurons in the vestibular system. The spontaneous and mechanically evoked spike discharges of vestibular nerve fibers were extracellularly recorded in isolated inner ear from the axolotl(More)
The structural elements of the nitric oxide-cyclic guanosine monophosphate (NO-cGMP) signaling pathway have been described in the vestibular peripheral system. However, the functions of NO in the vestibular endorgans are still not clear. We evaluated the action of NO on the Ca(2+) currents in hair cells isolated from the semicircular canal crista ampullaris(More)
A system for on-line spike detection and analysis based on an IBM PC/AT compatible computer, written in TURBO PASCAL 6.0 and using commercially available analog-to-digital hardware is described here. Spikes are detected by an adaptive threshold which varies as a function of signal mean and its variability. Since the threshold value is determined(More)