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  • Ann M. Graybiel, Rosario Moratalla, Harold A. Robertson
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 1990 (First Publication: 1 September 1990)
  • Amphetamine and cocaine are stimulant drugs that act on central monoaminergic neurons to produce both acute psychomotor activation and long-lasting behavioral effects including addiction andContinue Reading
  • Nancy Pavón, Ana Borda Martín, Ainhoa Mendialdua, Rosario Moratalla
  • Medicine, Psychology
  • Biological Psychiatry
  • 2006 (First Publication: 1 January 2006)
  • BACKGROUND The dopamine precursor 3,4-dihydroxyphenyl-L-alanine (L-DOPA) is currently the most efficacious noninvasive therapy for Parkinson's disease. A major complication of this therapy, however,Continue Reading
  • Jinhui Chen, Zhihui Huang, +6 authors Michael A Schwarzschild
  • Biology, Medicine
  • The Journal of Neuroscience
  • 1999 (First Publication: 1 November 1999)
  • Extracellular adenosine critically modulates ischemic brain injury, at least in part through activation of the A1 adenosine receptor. However, the role played by the A2A receptor has been obscured byContinue Reading
  • Ming Xu, Rosario Moratalla, Lisa H. Gold, Noboru Hiroi, Susumu Tonegawa
  • Biology, Medicine
  • Cell
  • 1994 (First Publication: 1 November 1994)
  • The brain dopaminergic system is a critical modulator of basal ganglia function and plasticity. To investigate the contribution of the dopamine D1 receptor to this modulation, we have used geneContinue Reading
  • Paulina Carriba, Oskar Ortiz, +14 authors Sergi Ferré
  • Medicine, Biology
  • Neuropsychopharmacology
  • 2007 (First Publication: 1 November 2007)
  • The mechanism of action responsible for the motor depressant effects of cannabinoids, which operate through centrally expressed cannabinoid CB1 receptors, is still a matter of debate. In the presentContinue Reading
  • Sanja Darmopil, Ana Borda Martín, Irene Ruiz de Diego, Sara Ares, Rosario Moratalla
  • Psychology, Medicine
  • Biological Psychiatry
  • 2009 (First Publication: 1 September 2009)
  • BACKGROUND Pharmacologic studies have implicated dopamine D1-like receptors in the development of dopamine precursor molecule 3,4-dihydroxyphenyl-L-alanine (L-DOPA)-induced dyskinesias and associatedContinue Reading
  • Ming Xu, Xiu-Ti Hu, Donald C. Cooper, Rosario Moratalla, Susumu Tonegawa
  • Medicine, Biology
  • Cell
  • 1994 (First Publication: 1 December 1994)
  • The brain mesoaccumbens dopamine system is intricately involved in the psychomotor stimulant activities of cocaine. However, the extent to which different dopamine receptors mediate these effects hasContinue Reading