Rosana Esteller

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Mechanisms underlying seizure generation are traditionally thought to act over seconds to minutes before clinical seizure onset. We analyzed continuous 3- to 14-day intracranial EEG recordings from five patients with mesial temporal lobe epilepsy obtained during evaluation for epilepsy surgery. We found localized quantitative EEG changes identifying(More)
Epileptic seizure prediction has steadily evolved from its conception in the 1970s, to proof-of-principle experiments in the late 1980s and 1990s, to its current place as an area of vigorous, clinical and laboratory investigation. As a step toward practical implementation of this technology in humans, we present an individualized method for selecting(More)
Brief bursts of focal, low amplitude rhythmic activity have been observed on depth electroencephalogram (EEG) in the minutes before electrographic onset of seizures in human mesial temporal lobe epilepsy. We have found these periods to contain discrete, individualized synchronized activity in patient-specific frequency bands ranging from 20 to 40 Hz. We(More)
OBJECTIVE To develop a prospective method for optimizing seizure prediction, given an array of implanted electrodes and a set of candidate quantitative features computed at each contact location. METHODS The method employs a genetic-based selection process, and then tunes a probabilistic neural network classifier to predict seizures within a 10 min(More)
OBJECTIVE Increases in accumulated energy on intracranial EEG are associated with oncoming seizures in retrospective studies, supporting the idea that seizures are generated over time. Published seizure prediction methods require comparison to 'baseline' data, sleep staging, and selecting seizures that are not clustered closely in time. In this study, we(More)
OBJECTIVE To evaluate the sensitivity of quantitative EEG (QEEG) for electrographic seizure identification in the intensive care unit (ICU). METHODS Six-hour EEG epochs chosen from 15 patients underwent transformation into QEEG displays. Each epoch was reviewed in 3 formats: raw EEG, QEEG + raw, and QEEG-only. Epochs were also analyzed by a proprietary(More)
The fractal dimension of a waveform represents a powerful tool for transient detection. In particular, in analysis of electroencephalograms and electrocardiograms, this feature has been used to identify and distinguish specific states of physiologic function. A variety of algorithms are available for the computation of fractal dimension. In this study, the(More)
available therapy. In most cases, this is focal epilepsy, in which seizures arise from a region of abnormal brain, the epileptic focus, and spread in a stereotyped, individualized fashion. 50 years ago, Penfield and colleagues found localized abnormal discharges on the EEG prior Brian Litt,1,7 Rosana Esteller,2,6 Javier Echauz,2,3 Maryann D’Alessandro,2(More)