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Interaction of Reelin with Amyloid Precursor Protein Promotes Neurite Outgrowth
The processing of amyloid precursor protein (APP) to Aβ is an important event in the pathogenesis of Alzheimer's disease, but the physiological function of APP is not well understood. Our previousExpand
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Olig1 and Olig2 triplication causes developmental brain defects in Down syndrome
Over-inhibition is thought to be one of the underlying causes of the cognitive deficits in Ts65Dn mice, the most widely used model of Down syndrome. We found a direct link between gene triplicationExpand
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Cell Migration along the Lateral Cortical Stream to the Developing Basal Telencephalic Limbic System
During embryogenesis, the lateral cortical stream (LCS) emerges from the corticostriatal border (CSB), the boundary between the developing cerebral cortex and striatum. The LCS is comprised of a mixExpand
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Emx1-Lineage Progenitors Differentially Contribute to Neural Diversity in the Striatum and Amygdala
In the developing mammalian basal telencephalon, neural progenitors from the subpallium generate the majority of inhibitory medium spiny neurons (MSNs) in the striatum, while both pallial- andExpand
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Differential regulation of telencephalic pallial-subpallial boundary patterning by Pax6 and Gsh2.
In the embryonic telencephalon, the pallial-subpallial boundary (PSB) separates the dorsal Pax6+ pallium from the ventral Gsh2+ subpallium. Previous studies have revealed that this region is a sourceExpand
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In vivo quantum dot labeling of mammalian stem and progenitor cells
Fluorescent semiconductor nanocrystal quantum dots (QDs) are a class of multifunctional inorganic fluorophores that hold great promise for clinical applications and biomedical research. Because noExpand
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Comparative analysis of extra-ventricular mitoses at early stages of cortical development in rat and human
Embryonic germinal zones of the dorsal and ventral telencephalon generate cortical neurons during the final week of gestation in rodent and during several months in human. Whereas the vast majorityExpand
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Tract-Tracing in Developing Systems and in Postmortem Human Material Using Carbocyanine Dyes
Rapid progress in neurobiology and genetics demands knowledge of fundamental aspects of brain development including the connectivity patterns within developing and adult brains. The primary focus ofExpand
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Does Prenatal Exposure to Maternal Inflammation Causes Sex Differences in Schizophrenia-Related Behavioral Outcomes in Adult Rats?
Highlighted Research Paper: Maternal Immune Activation during Pregnancy Alters the Behavior Profile of Female Offspring of Sprague Dawley Rats, by Brittney R. Lins, Wendie N. Marks, Nadine K. Zabder,Expand
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Partial, Rather than Full, BACE1 Inhibition May Be a Better Therapeutic Strategy for Alzheimer’s Disease Due to Effects of Complete Loss of BACE1 Activity on Adult Hippocampal Neurogenesis
Highlighted Research Paper: BACE1 Regulates Proliferation and Neuronal Differentiation of Newborn Cells in the Adult Hippocampus in Mice by, Zena K. Chatila, Eunhee Kim, Clara Berlé, EnjanaExpand
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