The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14
- Rosalind C. Lee, R. Feinbaum, V. Ambros
- BiologyCell
- 3 December 1993
An Extensive Class of Small RNAs in Caenorhabditis elegans
- Rosalind C. Lee, V. Ambros
- BiologyScience
- 26 October 2001
Using bioinformatics and cDNA cloning, this work found 15 new miRNA genes in C. elegans that express small transcripts that vary in abundance during larval development, and three of them have apparent homologs in mammals and/or insects.
The Cold Shock Domain Protein LIN-28 Controls Developmental Timing in C. elegans and Is Regulated by the lin-4 RNA
- E. Moss, Rosalind C. Lee, V. Ambros
- BiologyCell
- 7 March 1997
MicroRNAs and Other Tiny Endogenous RNAs in C. elegans
- V. Ambros, Rosalind C. Lee, Ann Lavanway, P. Williams, D. Jewell
- BiologyCurrent Biology
- 13 May 2003
Interacting endogenous and exogenous RNAi pathways in Caenorhabditis elegans.
- Rosalind C. Lee, C. Hammell, V. Ambros
- BiologyRNA: A publication of the RNA Society
- 1 April 2006
Microarray expression profiling of RNAi-defective mutant worms further suggests diverse endogenous RNAi pathways for silencing different sets of genes in C. elegans.
Potent effect of target structure on microRNA function
- Dang D. Long, Rosalind C. Lee, P. Williams, C. Chan, V. Ambros, Ye Ding
- BiologyNature Structural &Molecular Biology
- 1 April 2007
A potent effect of target structure on target recognition by miRNAs is indicated and a structure-based framework for genome-wide identification of animal miRNA targets is established.
A short history of a short RNA
- Rosalind C. Lee, R. Feinbaum, V. Ambros
- BiologyCell
- 23 January 2004
Circulating microRNA profiles in human patients with acetaminophen hepatotoxicity or ischemic hepatitis
- Jeanine A Ward, Chitra Kanchagar, V. Ambros
- Biology, MedicineProceedings of the National Academy of Sciences
- 4 August 2014
Significance Hundreds of microRNAs become dramatically elevated in the plasma or serum of acetaminophen (APAP) overdose patients and then recover back toward normal during successful treatment with…
Identification of microRNAs and other tiny noncoding RNAs by cDNA cloning.
- V. Ambros, Rosalind C. Lee
- BiologyMethods in molecular biology
- 2004
Methods are described for the construction of cDNA libraries from small noncoding RNAs through the use of T4 RNA ligase, reverse transcriptase, and polymerase chain reaction to confirm the expression of small RNAs in vivo.
The C. elegans heterochronic gene lin-46 affects developmental timing at two larval stages and encodes a relative of the scaffolding protein gephyrin
- A. Pepper, Jill E McCane, E. Moss
- BiologyDevelopment
- 1 May 2004
The findings suggest that the LIN-46 protein acts as a scaffold for a multiprotein assembly that controls developmental timing, and expand the known roles of gephyrin-related proteins to development.
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