Rosa R Bernabé

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The International Cancer Genome Consortium (ICGC) was launched to coordinate large-scale cancer genome studies in tumours from 50 different cancer types and/or subtypes that are of clinical and societal importance across the globe. Systematic studies of more than 25,000 cancer genomes at the genomic, epigenomic and transcriptomic levels will reveal the(More)
In limiting dilution analysis, the absolute frequencies of lipopolysaccharide-reactive B cell precursors producing anti-trinitrophenyl antibodies or the MOPC460 idiotype were studied in BALB/c mice, either normal, or immunized with antigen (Ab1), the idiotype (Ab2), or a monoclonal anti-idiotype antibody (Ab3). Anti-idiotype immunity results in the(More)
Phase II clinical trial with pegylated liposomal doxorubicin (CAELYX Õ /Doxil Õ) and quality of life evaluation (EORTC QLQ-C30) in adult patients with advanced soft tissue sarcomas Abstract Background: Pegylated liposomal doxorubicin (PLD), a formulation with pharmacokinetic differences with respect to doxorubicin (DXR), might benefit patients with advanced(More)
Immunoglobulin variable-region (V) genes, it is now recognized, do not encode specific receptors for T lymphocytes. Classical observations on T-cell expression of immunoglobulin idiotypes had remained unexplained until recent experiments showed that immunoglobulin idiotypes expressed by T lymphocytes in normal mice are absent in cells of the same(More)
Lung cancer remains the most commonly diagnosed cancer worldwide and the leading cause of cancer-related mortality. More than 80 % of all newly diagnosed cases of lung cancer are non-small cell lung cancer (NSCLC). Despite recent advances, 40 % of patients still have advanced disease at the moment of diagnosis. Clinical information, pathological diagnosis(More)
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