Rosa M Lamuela-Raventos

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BACKGROUND Observational cohort studies and a secondary prevention trial have shown an inverse association between adherence to the Mediterranean diet and cardiovascular risk. We conducted a randomized trial of this diet pattern for the primary prevention of cardiovascular events. METHODS In a multicenter trial in Spain, we randomly assigned participants(More)
Research has shown that fruits and vegetables containing high levels of polyphenolics (flavonoids) display high total antioxidant activity. Our laboratory found that various fruit and vegetable extracts, particularly blueberry (BB), were effective in reversing age-related deficits in neuronal signaling and behavioral parameters following 8 weeks of feeding,(More)
OBJECTIVE Independently of total caloric intake, a better quality of the diet (for example, conformity to the Mediterranean diet) is associated with lower obesity risk. It is unclear whether a brief dietary assessment tool, instead of full-length comprehensive methods, can also capture this association. In addition to reduced costs, a brief tool has the(More)
BACKGROUND Epidemiologic studies have suggested associations between flavonoid intake and health benefits. Traditional Mediterranean diets consist of a high consumption of plant products rich in flavonoids. OBJECTIVE This study estimates dietary flavonoid intake and main food sources in a Mediterranean population (Spanish adults). DESIGN The study(More)
BACKGROUND Epidemiologic studies have suggested that flavonoid intake plays a critical role in the prevention of coronary heart disease. Because atherosclerosis is considered a low-grade inflammatory disease, some feeding trials have analyzed the effects of cocoa (an important source of flavonoids) on inflammatory biomarkers, but the results have been(More)
OBJECTIVE To assess the effectiveness of an intervention aimed to increase adherence to a Mediterranean diet. DESIGN A 12-month assessment of a randomized primary prevention trial. SUBJECTS/SETTINGS One thousand five hundred fifty-one asymptomatic persons aged 55 to 80 years, with diabetes or > or =3 cardiovascular risk factors. INTERVENTION(More)
Cohort Profile: Design and methods of the PREDIMED study Miguel Ángel Martı́nez-González,1*y Dolores Corella, Jordi Salas-Salvadó, Emilio Ros, Marı́a Isabel Covas, Miquel Fiol, Julia Wärnberg, Fernando Arós, Valentina Ruı́z-Gutiérrez, Rosa Marı́a Lamuela-Raventós, Jose Lapetra, Miguel Ángel Muñoz, José Alfredo Martı́nez, Guillermo Sáez, Lluis Serra-Majem,(More)
Liquid chromatography coupled with ionspray mass spectrometry in the tandem mode (LC/MS/MS) with negative ion detection was used for the identification of a variety of phenolic compounds in a cocoa sample. Gradient elution with water and acetonitrile, both containing 0.1% HCOOH, was used. Standard solutions of 31 phenolic compounds, including benzoic and(More)
This paper describes for the first time a complete characterisation of the phenolic compounds in different anatomical parts of the Albariño grape. The application of high-performance liquid chromatography coupled with two complementary techniques, hybrid quadrupole time-of-flight and triple-quadrupole mass spectrometry, allowed the phenolic composition of(More)
Resveratrol has been shown to have beneficial effects on diseases related to oxidant and/or inflammatory processes and extends the lifespan of simple organisms including rodents. The objective of the present study was to estimate the dietary intake of resveratrol and piceid (R&P) present in foods, and to identify the principal dietary sources of these(More)