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INTRODUCTION The K-SADS-PL diagnostic interview is useful for the cross-sectional and longitudinal evaluation of psychopathology in children and adolescents. The objective of this article was to describe the interrater reliability of the Spanish version of the Schedule for Affective Disorders and Schizophrenia for School-Age Children--Present and Lifetime(More)
INTRODUCTION A fundamental precondition for early intervention in schizophrenia is accurate detection of prodromal states, that is, sign and symptom constellations that predict the onset of psychosis in persons with no prior background. Several structured interviews have been designed for the detection of prodromal subjects. OBJECTIVE To translate and(More)
Compared with the adult disorder, depression in children exhibits differences in its neurobiology, particularly in the HPA axis regulation. The bases of such differences can be evaluated in animal models of depression. The objective of the present study was to determine age and sex differences of Wistar rats in the forced swimming test (FST). The influence(More)
UNLABELLED Sex differences in the prevalence of obsessive-compulsive disorder (OCD) in prepubertal children have been described. Deficits on spontaneous alternation behavior (SAB) have been proposed as an animal model of OCD. OBJECTIVES To explore possible sex differences in the ontogeny of SAB and in the effect of the 5-HT1A agonist, 8-OH-hydroxy-2(More)
RATIONALE Subtypes of obsessive-compulsive disorder (OCD) related to age could determine differential response to treatment. OBJECTIVES To explore possible age differences in the effect of clomipramine in an animal model of OCD. METHODS The deficits on spontaneous alternation produced by 8-OH-DPAT and the preventing actions of clomipramine, desipramine(More)
The putative age difference in the effect of chronically administered quinpirole (0.125 and 0.5 mg/kg, 11 injections) on alternation in a T maze was studied. Male juvenile (43 days old) and adult (around 90 days old) rats exhibited similar control values of alternation. In adults, quinpirole (0.5 mg/kg) produced a drastic perseveration after 10 and 11(More)
BACKGROUND Since the introduction of antipsychotics, especially the so called atypicals, the treatment of schizophrenia has shown important improvements. At the present time, it is preferred to label clozapine and other antipsychotics sharing similar profiles as second-generation antipsychotics (SGAs). These medications have been proposed by some experts as(More)
An open-label, 8-week, follow-up study was designed to compare subjects with child versus adult onset of obsessive compulsive disorder (OCD) on their clinical characteristics and response to a standardized treatment with clomipramine. The study included 15 children and 13 adults with Diagnostic and Statistical Manual of Mental Disorders, 4th edition(More)
INTRODUCTION There are two phenotypes proposed for the psychotic disorders based on premorbid functioning and probably related with the duration of untreated psychosis (DUP). The aim of this study was to compare the clinical features, premorbid functioning and its relationship with DUP by gender in a group of first episode psychosis patients. METHODS We(More)
Amoxapine is marketed as an antidepressant. However, its in-vitro profile, receptor occupancy and preclinical effects are very similar to atypical antipsychotics. Amoxapine has also shown efficacy as an atypical antipsychotic in open trials. The objective of this study was to compare the antipsychotic and side effect profile of amoxapine and risperidone in(More)