Rory A Crabbe

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We enrolled 125 neurologically normal patients with intracranial aneurysms in a multi-institution, prospective, double-blind, randomized, placebo-controlled trial within 96 hours of their subarachnoid hemorrhage, to determine whether treatment with the calcium blocker nimodipine would prevent or reduce the severity of ischemic neurologic deficits from(More)
Age is a major risk factor for heart disease, and cardiac aging is characterized by elevated mitochondrial reactive oxygen species (ROS) with compromised mitochondrial and nuclear DNA integrity. To assess links between increased ROS levels and mutations, we examined in situ levels of ROS and cII mutation frequency, pattern and spectrum in the heart of(More)
The Big Blue lacI mutation detection assay is well validated and has permitted detailed analysis of spontaneous mutations in individual tissues over the lifespan of the mouse. In a recent assay of spontaneous mutations, a novel lacI mutation (C354T) recurred in six of seven mutants with a second mutation. The frequency of spontaneous doublets (mutants with(More)
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