Roque Enrique López

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The glucocorticoid receptor was characterized in biopsy samples from patients with recurrent malignant melanoma. Glucocorticoid receptors were measured by the charcoal-adsorption technique. Tumor cytosol from approximately 86% (25/29) of the patients contained large quantities of receptors (20-324 fmol/mg protein). The dissociation constant of this(More)
The glucocorticoid receptors were measured and characterized in the transplantable B16 murine melanoma using [3H]-dexamethasone by a charcoal adsorption technique. In the tumor cytosols assayed, the levels of receptors ranged from 44 to 200 fmol/mg protein, and the corresponding Kd's ranged from 2 to 43 nM. Sucrose density gradient analysis showed a peak(More)
Tumor biopsies from 68 patients with malignant melanoma were assessed for estrogen receptor (ERc) binding, and 32 of these for progesterone receptor (PRc) binding. Twenty-five patients (37%) had ERc greater than or equal to 5 fmols/mg protein; 14 patients (44%) had PRc greater than or equal to 10 fmols/mg of protein. There was no significant difference(More)
SentiStrength is a well-known tool for opinion mining texts circulated in social networks. There are English, Spanish, Russian versions of SentiStrength, which demonstrated their advantages in numerous examples. In the paper we present our classifier of opinions for analysis of comments from the Peruvian Facebook and Twitter. We corrected and enriched(More)
A case-control study was undertaken to evaluate the possible relationship between cholecystectomy and right colon cancer. Two hundred patients with adenocarcinoma of the cecum or ascending colon (diagnosed between 1984 and 1989) were compared with 200 matched neighborhood controls. Cholecystectomy history was obtained through interviews using structured(More)
An experimental study was designed to evaluate the effects of both a high fat diet and a cholecystectomy on the incidence of carcinogen-induced colon cancer in mice. Sixty pink-eyed jax (P/J) mice were divided equally into two groups. One group was fed a standard rodent diet and the other group received a diet supplemented with 20% corn oil. From each diet(More)