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- Steffen Klamt, Hartmut Grammel, Ronny Straube, Robin Ghosh, Ernst Dieter Gilles
- Molecular systems biology
- 2008

Purple non-sulfur bacteria (Rhodospirillaceae) have been extensively employed for studying principles of photosynthetic and respiratory electron transport phosphorylation and for investigating the regulation of gene expression in response to redox signals. Here, we use mathematical modeling to evaluate the steady-state behavior of the electron transport… (More)

- Alexei F. Cheviakov, Michael J. Ward, Ronny Straube
- Multiscale Modeling & Simulation
- 2010

The mean first passage time (MFPT) is calculated for a Brownian particle in a spherical domain in R 3 that contains N small non-overlapping absorbing windows, or traps, on its boundary. For the unit sphere, the method of matched asymptotic expansions is used to derive an explicit three-term asymptotic expansion for the MFPT for the case of N small locally… (More)

- Daniel Coombs, Ronny Straube, Michael J. Ward
- SIAM Journal of Applied Mathematics
- 2009

A common scenario in cellular signal transduction is that a diffusing surface-bound molecule must arrive at a localized signaling region on the cell membrane before the signaling cascade can be completed. The question then arises of how quickly such signaling molecules can arrive at newly formed signaling regions. Here, we attack this problem by calculating… (More)

Biomembranes consist of a lipid bi-layer into which proteins are embedded to fulfill numerous tasks in localized regions of the membrane. Often, the proteins have to reach these regions by simple diffusion. Motivated by the observation that IP 3 receptor channels (IP 3 R) form clusters on the surface of the endoplasmic reticulum (ER) during ATP-induced… (More)

- W M Sullender, A M Arvin, +7 authors S Chapman
- Antimicrobial agents and chemotherapy
- 1987

Eighteen children from 3 weeks to 6.9 years of age were given an oral acyclovir suspension for herpes simplex or varicella-zoster virus infections. Thirteen patients who were 6 months to 6.9 years old received 600 mg/m2 per dose, and three infants and two children less than 2 years old were given 300 mg/m2 per dose. The drug was given four times a day,… (More)

- Ronny Straube
- Biophysical journal
- 2013

Regulation by covalent modification is a common mechanism to transmit signals in biological systems. The modifying reactions are catalyzed either by two distinct converter enzymes or by a single bifunctional enzyme (which may employ either one or two catalytic sites for its opposing activities). The reason for this diversification is unclear, but… (More)

- Ronny Straube
- PLoS Computational Biology
- 2014

Two-component signal transduction systems, where the phosphorylation state of a regulator protein is modulated by a sensor kinase, are common in bacteria and other microbes. In many of these systems, the sensor kinase is bifunctional catalyzing both, the phosphorylation and the dephosphorylation of the regulator protein in response to input signals.… (More)

- S A Spector, C Kennedy, +4 authors D D Richman
- The Journal of infectious diseases
- 1989

The inhibition of viremia and p24 core antigenemia in patients infected with human immunodeficiency virus (HIV) was evaluated in separate multicenter, double-blind, placebo-controlled trials of zidovudine and ribavirin. Of 29 patients (14 with AIDS and 15 with AIDS-related complex [ARC]) enrolled in the zidovudine study, 16 received 250 mg of zidovudine… (More)

- Ronny Straube, Dietrich Flockerzi, Stefan C Müller, Marcus J B Hauser
- The journal of physical chemistry. A
- 2005

We present a numerical method to identify possible candidates for quasi-stationary manifolds in complex reaction networks governed by systems of ordinary differential equations. Inspired by singular perturbation theory, we examine the ratios of certain components of the reaction rate vector. Those ratios that rapidly approach a nearly constant value define… (More)

- Fang Wei, Dongping Yang, Ronny Straube, Jianwei Shuai
- Physical review. E, Statistical, nonlinear, and…
- 2011

We asymptotically calculate the spatially averaged mean first passage time (MFPT) of a diffusing channel protein in a finite membrane patch containing a small absorbing anchor site. Different two-dimensional membrane geometries are considered including a circular, a square-shaped, a rectangular, and a cylindrical domain. The asymptotic expressions are found… (More)