Rongxia Liao

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MicroRNAs (miRNAs) are a class of recently discovered noncoding RNA genes that post-transcriptionally regulate gene expression. It is becoming clear that miRNAs play an important role in the regulation of gene translation during development. However, in mammals, expression data are principally based on whole tissue analysis and are still very incomplete. We(More)
Malignant hematologic diseases are highly malignant and refractory to conventional therapies. Ligand-mediated targeting of liposomal anticancer drugs to surface receptors expressed on malignant B cells can be an effective strategy for treating B-cell malignancies. BAFF plays an important role in the maintenance of normal B-cell development and homeostasis(More)
Local and distant recurrence of malignant tumors following radio- and/or chemotherapy correlates with poor prognosis of patients. Among the reasons for cancer recurrence, preexisting cancer stem cells (CSCs) are considered the most likely cause due to their properties of self-renewal, pluripotency, plasticity and tumorigenicity. It has been demonstrated(More)
Myelodysplastic syndrome (MDS) is a group of blood-related malignancies caused by disorders of hematopoietic stem cells (HSCs). It is mainly characterized by the ineffective hematopoiesis. Many MDS patients will transform into acute myeloid leukemia (AML) with poor prognosis, often due to infection, hemorrhage and death. However, the molecular mechanism(More)
The farnesoid X receptor (FXR) is a bile acid (BA)-activated nuclear receptor that plays a major role in the regulation of BA and lipid metabolism. Although modulation of FXR expression has been reported, the mechanisms underlying the regulation of human FXR are yet unclear. Functional assays showed that the -150/+29 nucleotides region from the first(More)
clinical protocol development; randomised controlled trials; the drafting and submission of research proposals to funding agencies, and communication skills. Students were given the task of independently formulating a clinical protocol on simple topics such as the bioavailability of iron from oral iron preparations, the testing of immunogenicity of(More)