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- Cyriac Kandoth, Nikolaus Schultz, +15 authors Douglas A. Levine
- Nature
- 2013
We performed an integrated genomic, transcriptomic and proteomic characterization of 373 endometrial carcinomas using array- and sequencing-based technologies. Uterine serous tumours and ∼25% of… (More)
- Celina G. Kleer, Qi Cao, +12 authors Arul M. Chinnaiyan
- Proceedings of the National Academy of Sciences…
- 2003
The Polycomb Group Protein EZH2 is a transcriptional repressor involved in controlling cellular memory and has been linked to aggressive prostate cancer. Here we investigate the functional role of… (More)
- Daniel J. Brat, Roel G. W. Verhaak, +304 authors Jianan Zhang
- The New England journal of medicine
- 2015
BACKGROUND
Diffuse low-grade and intermediate-grade gliomas (which together make up the lower-grade gliomas, World Health Organization grades II and III) have highly variable clinical behavior that… (More)
- Xiaoju Wang, Jianjun Yu, +12 authors Arul M. Chinnaiyan
- The New England journal of medicine
- 2005
BACKGROUND
New biomarkers, such as autoantibody signatures, may improve the early detection of prostate cancer.
METHODS
With a phage-display library derived from prostate-cancer tissue, we… (More)
- Rajal B Shah, Rohit Mehra, +10 authors Kenneth J. Pienta
- Cancer research
- 2004
Understanding the biology of prostate cancer metastasis has been limited by the lack of tissue for study. We studied the clinical data, distribution of prostate cancer involvement, morphology,… (More)
- Matthew Bott, Marie Brevet, +15 authors Marc Ladanyi
- Nature Genetics
- 2011
Malignant pleural mesotheliomas (MPMs) often show CDKN2A and NF2 inactivation, but other highly recurrent mutations have not been described. To identify additional driver genes, we used an integrated… (More)
- Adam J. Bass, Vesteinn Thorsson, +257 authors Jia Liu
- Nature
- 2014
Gastric cancer is a leading cause of cancer deaths, but analysis of its molecular and clinical characteristics has been complicated by histological and aetiological heterogeneity. Here we describe a… (More)
- Ronglai Shen, Debashis Ghosh, Arul M. Chinnaiyan
- BMC Genomics
- 2004
An increasing number of studies have profiled tumor specimens using distinct microarray platforms and analysis techniques. With the accumulating amount of microarray data, one of the most intriguing… (More)
- Ronglai Shen, Adam B. Olshen, Marc Ladanyi
- Bioinformatics
- 2009
MOTIVATION
The molecular complexity of a tumor manifests itself at the genomic, epigenomic, transcriptomic and proteomic levels. Genomic profiling at these multiple levels should allow an integrated… (More)
- Fang Fang, Sevin Turcan, +15 authors Timothy A. Chan
- Science translational medicine
- 2011
Cancer-specific alterations in DNA methylation are hallmarks of human malignancies; however, the nature of the breast cancer epigenome and its effects on metastatic behavior remain obscure. To… (More)