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Human endonuclease V as a repair enzyme for DNA deamination.
The human endonuclease V gene is located in chromosome 17q25.3 and encodes a 282 amino acid protein that shares about 30% sequence identity with bacterial endonuclease V. This study reportsExpand
The Hippo pathway effector YAP is an essential regulator of ductal progenitor patterning in the mouse submandibular gland
Salivary glands, such as submandibular glands (SMGs), are composed of branched epithelial ductal networks that terminate in acini that together produce, transport and secrete saliva. Here, we showExpand
Epigenetic Silencing of the Chaperone Cosmc in Human Leukocytes Expressing Tn Antigen*
Background: Tn4 B cells from a patient with Tn antigen-positive leukocytes lack transcripts of Cosmc. Results: The Cosmc promoter in Tn4 cells is methylated and 5-aza-2′-deoxycytidine treatmentExpand
Platelet biogenesis and functions require correct protein O-glycosylation
Platelets express a variety of membrane and secreted glycoproteins, but the importance of glycosylation to platelet functions is poorly understood. To explore the importance of O-glycosylation, weExpand
A novel fluorescent assay for T-synthase activity.
Loss of T-synthase (uridine diphosphate galactose:N-acetylgalactosaminyl-α1-Ser/Thr β3galactosyltransferase), a key enzyme required for the formation of mucin-type core 1 O-glycans, is observed inExpand
Insights from xanthine and uracil DNA glycosylase activities of bacterial and human SMUG1: switching SMUG1 to UDG.
Single-strand-selective monofunctional uracil DNA glycosylase (SMUG1) belongs to Family 3 of the uracil DNA glycosylase (UDG) superfamily. Here, we report that a bacterial SMUG1 ortholog in GeobacterExpand
Promoters of Human Cosmc and T-synthase Genes Are Similar in Structure, Yet Different in Epigenetic Regulation*
Background: Transcriptional regulation of human T-synthase and Cosmc is unknown. Results: Minimal promoters for Cosmc and T-synthase are located in CpG islands, and the promoter of Cosmc, but notExpand
Lysyl oxidase is associated with increased thrombosis and platelet reactivity.
Lysyl oxidase (LOX) is overexpressed in various pathologies associated with thrombosis, such as arterial stenosis and myeloproliferative neoplasms (MPNs). LOX is elevated in the megakaryocyticExpand
Identification of Distinct Glycoforms of IgA1 in Plasma from Patients with Immunoglobulin A (IgA) Nephropathy and Healthy Individuals*
Immunoglobulin A nephropathy (IgAN) is the most common form of glomerulonephritis worldwide and is histologically characterized by the deposition of IgA1 and consequent inflammation in the glomerularExpand
Repair of deaminated base damage by Schizosaccharomyces pombe thymine DNA glycosylase.
Thymine DNA glycosylases (TDG) in eukaryotic organisms are known for their double-stranded glycosylase activity on guanine/uracil (G/U) base pairs. Schizosaccharomyces pombe (Spo) TDG is a member ofExpand