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The Hippo pathway effector YAP is an essential regulator of ductal progenitor patterning in the mouse submandibular gland
TLDR
It is shown that Yap-induced Epiregulin signaling promotes the identity of SMG ductal progenitors and that removal of nuclear Yap by Lats1/2-mediated signaling is critical for proper ductal maturation.
Platelet biogenesis and functions require correct protein O-glycosylation
TLDR
It is demonstrated that extended O-glycans are required for normal biogenesis of the platelets as well as the expression and functions of their essential glycoproteins, and that variations in O- Glycosylation may contribute to altered hemostasis.
Epigenetic Silencing of the Chaperone Cosmc in Human Leukocytes Expressing Tn Antigen*
TLDR
Epigenetic silencing of Cosmc through hypermethylation of its promoter leads to loss of CosMC transcripts in Tn4 cells, an immortalized B cell line from a male patient with a Tn-syndrome-like phenotype, which may be important in understanding aberrant Tn antigen expression in human diseases.
A novel fluorescent assay for T-synthase activity.
TLDR
This new high-throughput assay allows for facile screening of tumor specimens and other biological material for T-synthase activity and could be used diagnostically.
Lysyl oxidase is associated with increased thrombosis and platelet reactivity.
TLDR
It is found that Pf4-Lox(tg/tg) platelets adhere better to collagen and have greater aggregation response to lower doses of collagen compared with controls, and this demonstrates that LOX enhances platelet activation and thrombosis.
Identification of Distinct Glycoforms of IgA1 in Plasma from Patients with Immunoglobulin A (IgA) Nephropathy and Healthy Individuals*
TLDR
It is demonstrated that undergalactosylation of O-glycans in IgA1 is not restricted to IgAN and suggested that in vivo inefficiency of T-synthase toward IgA 1 in a subpopulation of B or plasma cells, as well as overall elevation of IgA, may contribute to IgAn pathogenesis.
Promoters of Human Cosmc and T-synthase Genes Are Similar in Structure, Yet Different in Epigenetic Regulation*
TLDR
It is demonstrated that Cosmc and T-synthase are transcriptionally regulated at a basal level by the specificity protein/Krüppel-like transcription factor family of members, which explains their ubiquitous and coordinated expression, and also indicate that they are differentially epigenetically regulated beyond X chromosome imprinting.
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