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- Publications
- Influence
Transcriptome-wide off-target RNA editing induced by CRISPR-guided DNA base editors
- Julian Grünewald, Ronghao Zhou, +4 authors J. K. Joung
- Biology, Medicine
- Nature
- 17 April 2019
CRISPR–Cas base-editor technology enables targeted nucleotide alterations, and is being increasingly used for research and potential therapeutic applications1,2. The most widely used cytosine base… Expand
CRISPR DNA base editors with reduced RNA off-target and self-editing activities
- Julian Grünewald, Ronghao Zhou, +4 authors J. K. Joung
- Biology, Medicine
- Nature Biotechnology
- 25 July 2019
Cytosine or adenine base editors (CBEs or ABEs) can introduce specific DNA C-to-T or A-to-G alterations1–4. However, we recently demonstrated that they can also induce transcriptome-wide… Expand
A dual-deaminase CRISPR base editor enables concurrent adenine and cytosine editing
- Julian Grünewald, Ronghao Zhou, +7 authors J. K. Joung
- Chemistry, Medicine
- Nature Biotechnology
- 5 May 2020
Existing adenine and cytosine base editors induce only a single type of modification, limiting the range of DNA alterations that can be created. Here we describe a CRISPR–Cas9-based synchronous… Expand
CRISPR adenine and cytosine base editors with reduced RNA off-target activities
- Julian Grünewald, Ronghao Zhou, +4 authors J. Keith Joung
- Chemistry, Biology
- 9 May 2019
CRISPR-guided DNA base editors enable the efficient installation of targeted single-nucleotide changes. Cytosine or adenine base editors (CBEs or ABEs), which are fusions of cytidine or adenosine… Expand
CRISPR C-to-G base editors for inducing targeted DNA transversions in human cells
- I. Kurt, Ronghao Zhou, +5 authors J. K. Joung
- Chemistry, Medicine
- Nature Biotechnology
- 20 July 2020
CRISPR-guided DNA cytosine and adenine base editors are widely used for many applications 1 – 4 but primarily create DNA base transitions (that is, pyrimidine-to-pyrimidine or purine-to-purine). Here… Expand
Identification of the Factors Responsible for the Selective in vitro Cytotoxic Activity of Isoprenylated Coumarin Derivatives under Nutrient-deprived Conditions
- H. Zhang, Ronghao Zhou, +4 authors Dora Carrico-Moniz
- Biology, Medicine
- Journal of Cancer
- 1 January 2016
Pancreatic cancer is one of the most devastating forms of human cancer. The lack of effective clinical treatments for pancreatic cancer has led to one of the lowest five-year survival rates among all… Expand
Investigation of the Antiproliferative Mechanism of Novel Isoprenylated Coumarin Compounds Against Pancreatic Cancer Cells
- Ronghao Zhou
- Chemistry
- 2016
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