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Transcriptome-wide off-target RNA editing induced by CRISPR-guided DNA base editors
CRISPR–Cas base-editor technology enables targeted nucleotide alterations, and is being increasingly used for research and potential therapeutic applications1,2. The most widely used cytosine baseExpand
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CRISPR DNA base editors with reduced RNA off-target and self-editing activities
Cytosine or adenine base editors (CBEs or ABEs) can introduce specific DNA C-to-T or A-to-G alterations1–4. However, we recently demonstrated that they can also induce transcriptome-wideExpand
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A dual-deaminase CRISPR base editor enables concurrent adenine and cytosine editing
Existing adenine and cytosine base editors induce only a single type of modification, limiting the range of DNA alterations that can be created. Here we describe a CRISPR–Cas9-based synchronousExpand
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CRISPR adenine and cytosine base editors with reduced RNA off-target activities
CRISPR-guided DNA base editors enable the efficient installation of targeted single-nucleotide changes. Cytosine or adenine base editors (CBEs or ABEs), which are fusions of cytidine or adenosineExpand
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CRISPR C-to-G base editors for inducing targeted DNA transversions in human cells
CRISPR-guided DNA cytosine and adenine base editors are widely used for many applications 1 – 4 but primarily create DNA base transitions (that is, pyrimidine-to-pyrimidine or purine-to-purine). HereExpand
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Identification of the Factors Responsible for the Selective in vitro Cytotoxic Activity of Isoprenylated Coumarin Derivatives under Nutrient-deprived Conditions
Pancreatic cancer is one of the most devastating forms of human cancer. The lack of effective clinical treatments for pancreatic cancer has led to one of the lowest five-year survival rates among allExpand
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Investigation of the Antiproliferative Mechanism of Novel Isoprenylated Coumarin Compounds Against Pancreatic Cancer Cells
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