CD80 in immune suppression by mouse ovarian carcinoma-associated Gr-1+CD11b+ myeloid cells.
- Rongcun Yang, Z. Cai, Yuan Zhang, W. Yutzy, K. Roby, R. Roden
- Biology, MedicineCancer Research
- 1 July 2006
CD80-dependent responses to myeloid suppressor cells may contribute to tumor tolerance and the progression of ovarian carcinoma.
Both miR-17-5p and miR-20a Alleviate Suppressive Potential of Myeloid-Derived Suppressor Cells by Modulating STAT3 Expression
The results suggest that miR-17-5p and mi-20a could potentially be used for immunotherapy against diseases, especially cancer, by blocking STAT3 expression.
Multi-functionalized graphene oxide based anticancer drug-carrier with dual-targeting function and pH-sensitivity
The results show that this multi-functionalized GO has potential applications for targeted delivery and the controlled release of anticancer drugs.
B7-H1 on myeloid-derived suppressor cells in immune suppression by a mouse model of ovarian cancer.
Regulation of arginase I activity and expression by both PD-1 and CTLA-4 on the myeloid-derived suppressor cells
There may exist a coinhibitory and costimulatory molecules-based immuno-regulating wet among MDSCs, which regulated the activity and expression of arginase I in mice bearing ovarian 18D carcinoma and showed reduced suppressive potential of PD-1+CTLA-4+MDSCs.
Cell Surface-Binding Motifs of L2 That Facilitate Papillomavirus Infection
- Rongcun Yang, P. Day, W. Yutzy, Ken Y. Lin, C. Hung, R. Roden
- BiologyJournal of Virology
- 15 March 2003
Mutation of L2 residues 18 and 19 or 21 and 22 significantly reduces both the ability of the HPV16 L2 13-31-GFP fusion protein to bind to SiHa cells and the infectivity of HPV16 pseudovirions.
Delivery of Telomerase Reverse Transcriptase Small Interfering RNA in Complex with Positively Charged Single-Walled Carbon Nanotubes Suppresses Tumor Growth
The functionalized SWNTs could facilitate the coupling of siRNAs that specifically target murine TERT expression to form the mTERT siRNA:SWNT+ complex, and may represent a new class of molecular transporters applicable for siRNA therapeutics.
Interaction of tSNARE Syntaxin 18 with the Papillomavirus Minor Capsid Protein Mediates Infection
Genetic studies identified a highly conserved L2 domain, DKILK, comprising residues 40 to 44 that mediated BPV1 trafficking through the ER during infection via an interaction with the tSNARE syntaxin 18.
Papillomavirus-Like Particles Stimulate Murine Bone Marrow-Derived Dendritic Cells To Produce Alpha Interferon and Th1 Immune Responses via MyD88
Analysis of transcriptional responses of murine BMDCs by microarray suggested that alpha/beta interferon (IFN-α/β) transcripts and numerous proinflammatory cytokines and chemokines are up regulated in response to HPV16 VLPs, and implicates TLR recognition as central to immune recognition of HPV16 L1 VLLP.
miR‐223 suppresses differentiation of tumor‐induced CD11b+Gr1+myeloid‐derived suppressor cells from bone marrow cells
Interestingly, miR‐223 remarkably inhibits differentiation of BMCs into CD11b+Gr1+MDSCs in the presence of tumor‐associated factors by targeting myocyte enhancer factor 2C (MEF2C) and its targeting molecule MEF1C increases the number of MDSCs.