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CD80 in immune suppression by mouse ovarian carcinoma-associated Gr-1+CD11b+ myeloid cells.
CD80-dependent responses to myeloid suppressor cells may contribute to tumor tolerance and the progression of ovarian carcinoma. Expand
Cell Surface-Binding Motifs of L2 That Facilitate Papillomavirus Infection
Mutation of L2 residues 18 and 19 or 21 and 22 significantly reduces both the ability of the HPV16 L2 13-31-GFP fusion protein to bind to SiHa cells and the infectivity of HPV16 pseudovirions. Expand
Multi-functionalized graphene oxide based anticancer drug-carrier with dual-targeting function and pH-sensitivity
A dual-targeting drug delivery and pH-sensitive controlled release system based on multi-functionalized graphene oxide (GO) was established in order to enhance the effect of targeted drug deliveryExpand
Delivery of Telomerase Reverse Transcriptase Small Interfering RNA in Complex with Positively Charged Single-Walled Carbon Nanotubes Suppresses Tumor Growth
The functionalized SWNTs could facilitate the coupling of siRNAs that specifically target murine TERT expression to form the mTERT siRNA:SWNT+ complex, and may represent a new class of molecular transporters applicable for siRNA therapeutics. Expand
Regulation of arginase I activity and expression by both PD-1 and CTLA-4 on the myeloid-derived suppressor cells
There may exist a coinhibitory and costimulatory molecules-based immuno-regulating wet among MDSCs, which regulated the activity and expression of arginase I in mice bearing ovarian 18D carcinoma and showed reduced suppressive potential of PD-1+CTLA-4+MDSCs. Expand
Interaction of tSNARE Syntaxin 18 with the Papillomavirus Minor Capsid Protein Mediates Infection
Genetic studies identified a highly conserved L2 domain, DKILK, comprising residues 40 to 44 that mediated BPV1 trafficking through the ER during infection via an interaction with the tSNARE syntaxin 18. Expand
B7-H1 on myeloid-derived suppressor cells in immune suppression by a mouse model of ovarian cancer.
It is suggested that expression of B7-H1 on Gr-1 (+)CD11b(+) myeloid cells triggered by the 1D8 mouse model of ovarian carcinoma suppresses antigen-specific immunity via interaction with PD-1 on CD4(+)CD25(+) Foxp3(+) regulatory T cells. Expand
Mesenchymal stem cells inhibit Th17 cell differentiation by IL-10 secretion.
The results show that bone marrow-derived MSCs were able to inhibit Th17 cell differentiation via interleukin (IL)-10 secretion, and suggest increased IL-10 secretion might be the key factor. Expand
miR‐223 suppresses differentiation of tumor‐induced CD11b+Gr1+myeloid‐derived suppressor cells from bone marrow cells
Interestingly, miR‐223 remarkably inhibits differentiation of BMCs into CD11b+Gr1+MDSCs in the presence of tumor‐associated factors by targeting myocyte enhancer factor 2C (MEF2C) and its targeting molecule MEF1C increases the number of MDSCs. Expand
Papillomavirus Capsid Mutation To Escape Dendritic Cell-Dependent Innate Immunity in Cervical Cancer
It is concluded that innate recognition of the intact L1 VLP structure via MyD88 is critical in the induction of high-titer neutralizing IgG in VLP-induced immune responses and its evasion during cervical carcinogenesis. Expand