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The present work contributes to the development of a powerful technical platform to rapidly identify and classify complicated components and metabolites for traditional Chinese medicines. In this process, notoginsenosides, the main active ingredients in Panaxnotoginseng, were chosen as model compounds. Firstly, the fragmental patterns, diagnostic product(More)
Ginseng has become one of the most commonly used alternative herbal medicines and its active component, ginsenoside Rg1, possesses known pharmacological effects, including anticancer properties. However, the effects of ginsenoside Rg1 on metastasis have not been investigated. The present study demonstrated that ginsenoside Rg1 was able to suppress(More)
BACKGROUND Phytochemical-mediated alterations in P-glycoprotein (P-gp) activity may result in herb-drug interactions by altering drug pharmacokinetics. Shengmai-san, a traditional Chinese herbal medicine composed by Panax Ginseng, Ophiopogon Japonicus, and Schisandra Chinensis, is routinely being used for treating various coronary heart diseases. In our(More)
AIM To establish a robust methodology for quantitative analysis of therapeutic peptide in biological samples. MATERIALS & METHODS Octreotide was chosen as a model therapeutic peptide, and oxidized-octreotide was synthesized as internal standard. Protein precipitation combining liquid-liquid extraction technique was adopted to enhance the recovery and(More)
A two-step chemical modification process is designed for synthesizing novel diamine-functionalized mesopolymers, which combine the advantage of organic polymers and mesoporous materials, and serve as an efficient scaffold for supporting highly dispersed, catalytically active and robust Pd nanoparticles (NPs).
It is ideal and desirable for a single instrument to meet the requirement of both qualitative and quantitative analysis of complicated components in pharmacokinetic research for herbal medicine. Liquid chromatography combined with hybrid ion trap and time-of-flight mass spectrometry (LCMS-IT-TOF) was recently confirmed as a very powerful tool for the(More)
In this paper, we report a new strategy for electrochemical DNA detection in homogeneous solution based on the host-guest molecule recognition technique. In this sensing protocol, a novel dually labeled DNA probe (DLP) in a stem-loop structure was employed, which was designed with dabcyl labeled at one end as a guest molecule, and with Au nanoparticle(More)
To study pharmacokinetics behavior of Raltitrexed (RTX) after single injected with Radix Astragali (RA); twelve rats were divided into two groups: RTX (administrated iv. of raltitrexed); RTX with RA (administrated iv. of raltitrexed after single iv. dose of 3. 15 g x kg(-1)), rat plasma was collected and processed before HPLC assays; The established HPLC(More)
Notoginsenosides, the main active gradients of Chinese traditional medicine Panax notoginseng, possesses a variety of biological activities including antioxidant property, anti-hyperglycemic, anti-obese, etc. However, pharmacokinetic evaluation for notoginsenosides is still a formidable task due to their low concentrations and complex components in vivo.(More)
A versatile photocatalyst has been prepared by grafting palladium phthalocyaninesulfonate (PdPcS) onto the FDU-14 mesopolymer with 3-D cubic mesostructure (FDU-14-PdPcS) via multi-step chemical modification processes. The FDU-14-PdPcS was characterized by the X-ray diffraction (XRD), diffuse reflectance UV-vis spectroscopy and inductively coupled plasma(More)