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Quantitative Peptidomics Study Reveals That a Wound-Induced Peptide from PR-1 Regulates Immune Signaling in Tomato[W][OPEN]
TLDR
A role for PR-1 in immune signaling is highlighted and the potential application of plant endogenous peptides in efforts to defeat biological threats in crop production is suggested. Expand
PPARgamma rescue of the mitochondrial dysfunction in Huntington's disease
TLDR
The results reveal that TZD and rosiglitazone may play a protective role in HD, and support the view that PPARγ is a potential therapeutic target in HD. Expand
Metformin activation of AMPK-dependent pathways is neuroprotective in human neural stem cells against Amyloid-beta-induced mitochondrial dysfunction.
TLDR
Understanding of the central role of AMPK in Aβ-related neuronal impairment is extended, and co-treatment with metformin significantly restored fragmented mitochondria to almost normal morphology in the hNSCs with Aβ. Expand
Metformin activation of AMPK suppresses AGE‐induced inflammatory response in hNSCs
TLDR
Co‐treatment with metformin significantly restored inducible nitric oxide synthase (iNOS) and cyclooxygenase‐2 (COX‐2) levels in AGE‐treated hNSCs and extended the understanding of the central role of AMPK in A GE induced inflammatory responses, which increase the risk of neurodegeneration in diabetic patients. Expand
Insecticidal action of mammalian galectin-1 against diamondback moth (Plutella xylostella).
TLDR
In vitro data showed that GAL1 interacts with chitosan/chitin in a dose-dependent manner, and also specifically binds to the PM in vitro, indicating that the protective function of the PM was disrupted by GAL2 treatment. Expand
The down-regulation of galectin-1 expression is a specific biomarker of arsenic toxicity.
TLDR
Galectin-1 gene knockdown mediates the apoptotic effects of arsenic in 3T3 and KB cells via regulation of the cellular arsenic levels, and it is proposed that down-regulation of GAL1 expression may be a useful and specific biomarker in assessing the toxicity of arsenic exposure. Expand
Why do Nettles Sting ? About Stinging Hairs Looking Simple but Acting Complex
To cope with environmental stress, plants have developed various defensive mechanisms against prey. For this purpose, some plants use external structures, like mechanical thorns and toxic stingingExpand
The apoptotic effect of green tea (-)-epigallocatechin gallate on 3T3-L1 preadipocytes depends on the Cdk2 pathway.
TLDR
Green tea catechins, especially (-)-epigallocatechin gallate (EGCG), were found to be more effective than EC, ECG, and EGC in changing the apoptotic signals and may relate to the mechanism by which EGCG modulates body weight. Expand
Rosiglitazone activation of PPARγ-dependent signaling is neuroprotective in mutant huntingtin expressing cells.
TLDR
It is shown that rosiglitazone upregulated the endogenous expression of PPARγ, its downstream target genes (including PGC1α, NRF-1 and Tfam) and mitochondrial function in mHtt expressing N2A cells, and this data support the concept thatPPARγ may be a novel therapeutic target for treating HD. Expand
Possible involvement of glutathione and p53 in trichloroethylene- and perchloroethylene-induced lipid peroxidation and apoptosis in human lung cancer cells.
TLDR
The data suggest that, in human lung cancer cells, GSH plays a vital role in the protection of TCE- and PERC-induced oxidative stress and apoptosis, which may be mediated through a p53-dependent pathway. Expand
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