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We present an integrated approach to identify genetic mechanisms that control self-renewal in mouse embryonic stem cells. We use short hairpin RNA (shRNA) loss-of-function techniques to downregulate a set of gene products whose expression patterns suggest self-renewal regulatory functions. We focus on transcriptional regulators and identify seven genes for(More)
Molecular regulation of embryonic stem cell (ESC) fate involves a coordinated interaction between epigenetic, transcriptional and translational mechanisms. It is unclear how these different molecular regulatory mechanisms interact to regulate changes in stem cell fate. Here we present a dynamic systems-level study of cell fate change in murine ESCs(More)
Establishing a functional network is invaluable to our understanding of gene function, pathways, and systems-level properties of an organism and can be a powerful resource in directing targeted experiments. In this study, we present a functional network for the laboratory mouse based on a Bayesian integration of diverse genetic and functional genomic data.(More)
This paper focuses on the problem of discovering users' topics of interest on Twitter. While previous efforts in modeling users' topics of interest on Twitter have focused on building a "bag-of-words" profile for each user based on his tweets, they overlooked the fact that Twitter users usually publish noisy posts about their lives or create conversation(More)
Specularities on surfaces with tangential hairs or grooves are readily observable in nature. Examples of such phenomena are the arched or looped highlights observed on horses and on human heads and the linear or curved specularities observed on parts of industrial machinery that have tangential grooves. We investigate the geometry of curvilinear(More)
Personal use of this material is permitted. However, permission to reprint/republish this material for advertising or promotional purposes or for creating new collective works for resale or redistribution to servers or lists, or to reuse any copyrighted component of this work in other works, must be obtained from the IEEE. Abstract Abstract ––(More)