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Heat-Shock Factor 1 (HSF1), master regulator of the heat-shock response, facilitates malignant transformation, cancer cell survival, and proliferation in model systems. The common assumption is that these effects are mediated through regulation of heat-shock protein (HSP) expression. However, the transcriptional network that HSF1 coordinates directly in(More)
We propose a novel significance measure for skeleton pruning, called bending potential ratio (BPR), in which the decision regarding whether a skeletal branch should be pruned or not is based on the context of the boundary segment that corresponds to the branch. By considering this contextual information, we can better evaluate the contribution of the(More)
Frequent embedded subtree pattern mining is an important data mining problem with broad applications. In this paper, we propose a novel embedded subtree mining algorithm, called PrefixTreeESpan (i.e. Prefix-Tree-projected Embedded-Subtree pattern), which finds a subtree pattern by growing a frequent prefix-tree. Thus, using divide and conquer, mining local(More)
A recommender system is a Web technology that proactively suggests items of interest to users based on their objective behavior or explicitly stated preferences. Evaluations of recommender systems (RS) have traditionally focused on the performance of algorithms. However, many researchers have recently started investigating system effectiveness and(More)
Collaborative filtering (CF), one of the most successful recommendation approaches, continues to attract interest in both academia and industry. However, one key issue limiting the success of collaborative filtering in certain application domains is the cold-start problem, a situation where historical data is too sparse (known as the sparsity problem), new(More)
Heat-shock factor 1 (HSF1) is the master transcriptional regulator of the cellular response to heat and a wide variety of other stressors. We previously reported that HSF1 promotes the survival and proliferation of malignant cells. At this time, however, the clinical and prognostic significance of HSF1 in cancer is unknown. To address this issue breast(More)
We conducted a user study evaluating two preference elicitation approaches based on ratings and personality quizzes respectively. Three criteria were used in this comparative study: perceived accuracy, user effort and user loyalty. Results from our study show that the perceived accuracy in two systems is not significantly different. However, users expended(More)