Rong Gu

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BACKGROUND Sympathetic overactivity and catecholamine accumulation are important characteristic findings in heart failure, which contribute to its pathophysiology. Here, we identify a potential mechanism underlying norepinephrine accumulation in a rat model of heart failure. METHODOLOGY/PRINCIPAL FINDINGS Initially, we constructed a rat model of(More)
—As a new area of machine learning research, the deep learning algorithm has attracted a lot of attention from the research community. It may bring human beings to a higher cognitive level of data. Its unsupervised pre-training step allows us to find high-dimensional representations or abstract features which work much better than the principal component(More)
—Artificial neural networks (ANNs) have been proved to be successfully used in a variety of pattern recognition and data mining applications. However, training ANNs on large scale datasets are both data-intensive and computation-intensive. Therefore, large scale ANNs are used with reservation for their time-consuming training to get high precision. In this(More)
—The frequent itemset mining (FIM) is one of the most important techniques to extract knowledge from data in many real-world applications. The Apriori algorithm is the widely-used algorithm for mining frequent itemsets from a transactional dataset. However, the FIM process is both data-intensive and computing-intensive. On one side, large scale data sets(More)
The social connections among users have significant impacts on UGC video systems. The goal of this paper is to study the social connectivity of such systems by measuring YouKu, the most popular UGC video system in China. We have collected 627 thousand user profiles, 3 million social connections and 13.6 million videos' information. The analysis results have(More)
BACKGROUND Integrin linked kinase (ILK), as an important component of mechanical stretch sensor, can initiate cellular signaling response in the heart when cardiac preload increases. Previous work demonstrated increased ILK expression could induce angiogenesis to improved heart function after MI. However the patholo-physiological role of ILK in cardiac(More)
MicroRNAs are involved in the regulation of various cellular processes, including cell apoptosis and autophagy. Expression of microRNA-99a (miR-99a) is reduced in apoptotic neonatal mice ventricular myocytes (NMVMs) subjected to hypoxia. We hypothesize that miR-99a might restore cardiac function after myocardial infarction (MI) by up-regulation of myocyte(More)