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Targeting the Thioredoxin System as a Strategy for Cancer Therapy.
This work highlights the specific relationship between TrxR and apoptotic signaling pathways, which influences reactive oxygen species (ROS) and further regulates the inflammatory signaling pathway, and discusses representative trxR inhibitors with anticancer activity. Expand
A new rhodium(I) NHC complex inhibits TrxR: In vitro cytotoxicity and in vivo hepatocellular carcinoma suppression.
Nine new designed rhodium(I) N-heterocyclic carbene (NHC) complexes were effective towards cancer cells, especially complex 1e was more active than cisplatin and manifested strong antiproliferative activity against HCC cells. Expand
A Gold(I) Complex Containing an Oleanolic Acid Derivative as a Potential Anti-ovarian Cancer Agent via Inhibiting TrxR and Activating ROS-mediated ERS.
It is shown that a gold(I) complex containing an oleanolic acid derivative induces ovarian cancer A2780 cells apoptosis by activating the endoplasmic reticulum stress (ERS) and can inhibit TrxR enzyme activity to elevate ROS, mediate ERS and mitochondrial dysfunction, finally leading to the A 2780 cells cycle arrest and apoptosis. Expand
Halo and Pseudohalo Gold(I)-NHC Complexes Derived from 4,5-Diarylimidazoles with Excellent in Vitro and in Vivo Anticancer Activity Against HCC.
Complex 6 can inhibit the expression of the thioredoxin reductase (TrxR) both in vitro and in vivo, block the HepG2 cells in the G2/M phase, induce reactive oxygen species (ROS) production, damage mitochondrial membrane potential (MMP) and promote HepG 2 cell apoptosis. Expand
Novel compounds that reverse the disease phenotype in Type 2 Gaucher disease patient-derived cells.
In an effort to identify small molecules which could be optimized for CNS penetration, tamoxifen was identified from a high throughput phenotypic screen on Type 2 GD patient-derived fibroblasts which reversed the disease phenotype. Expand
[Comparative analysis of volatile components of medicinal materials from Perilla frutescens].
It provides basis scientific explanation to the differences of traditional efficacy of medicinal materials from Perilla frutescens. Expand