Ronaldo Perez

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One of the pathological hallmarks of Alzheimer disease is the accumulation of amyloid plaques in the extracellular space in the brain. Amyloid plaques are primarily composed of aggregated amyloid β peptide (Aβ), a proteolytic fragment of the transmembrane amyloid precursor protein (APP). For APP to be proteolytically cleaved into Aβ, it must be internalized(More)
In sporadic Alzheimer's disease (AD), impaired Aβ removal contributes to elevated extracellular Aβ levels that drive amyloid plaque pathogenesis. Extracellular proteolysis, export across the blood-brain barrier, and cellular uptake facilitate physiologic Aβ clearance. Astrocytes can take up and degrade Aβ, but it remains unclear whether this function is(More)
Epidemiological studies show that patients with type 2 diabetes (T2DM) and individuals with a diabetes-independent elevation in blood glucose have an increased risk for developing dementia, specifically dementia due to Alzheimer's disease (AD). These observations suggest that abnormal glucose metabolism likely plays a role in some aspects of AD(More)
The paracellular pathway through the tight junction provides an important route for transepithelial chloride reabsorption in the kidney, which regulates extracellular salt content and blood pressure. Defects in paracellular chloride reabsorption may in theory cause deregulation of blood pressure. However, there is no evidence to prove this theory or to(More)
A rare Mendelian syndrome--pseudohypoaldosteronism type II (PHA-II)--features hypertension, hyperkalemia, and metabolic acidosis. Genetic linkage studies and exome sequencing have identified four genes--with no lysine kinase 1 (wnk1), wnk4, Kelch-like 3 (KLHL3), and Cullin 3 (Cul3)--mutations of which all caused PHA-II phenotypes. The previous hypothesis(More)
UNLABELLED In AD, an imbalance between Aβ production and removal drives elevated brain Aβ levels and eventual amyloid plaque deposition. APP undergoes nonamyloidogenic processing via α-cleavage at the plasma membrane, amyloidogenic β- and γ-cleavage within endosomes to generate Aβ, or lysosomal degradation in neurons. Considering multiple reports(More)
Ribonucleotide reductases (RNRs) catalyze nucleotide reduction via complex radical chemistry, providing deoxynucleotides for DNA synthesis in all domains of life. Many anaerobic bacteria and archaea contain the class III O2-sensitive RNR, and those that have been studied to date couple nucleotide reduction to formate oxidation. Here (pp. E3756–E3765) we(More)
We describe a decision support system to assist in the preparation and evaluation of agroindustrial investment projects, called Agriventure. This system has been specifically designed to address the special characteristics of agroindustrial projects. The system facilitates the laborious process of organizing the technical and economic information needed to(More)
Qingli Xiao,1 Ping Yan,1 Xiucui Ma,2,3 Haiyan Liu,2 Ronaldo Perez,1 Alec Zhu,1 Ernesto Gonzales,1 Jack M. Burchett,1 Dorothy R. Schuler,1 John R. Cirrito,1 Abhinav Diwan,2,3* and Jin-Moo Lee1* 1Department of Neurology and the Hope Center for Neurological Disorders and 2Division of Cardiology and Center for Cardiovascular Research, Washington University(More)
  • Aziz Galvão da Silva Júnior, Ronaldo Perez, Cosme Carvalho Ervilha
  • 2013
In the short and medium term, biofuels are the most viable alternative to reduce the environmental impact of fossil fuels. The recent controversy over the competition between biofuels and food production increases the complexity of investment decisions in the biodiesel production chain. In this context, decision support tools are highly relevant. The(More)
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