BACKGROUND
Whereas organized trauma care systems have decreased trauma mortality in the United States, trauma system design has not been well addressed in developing nations. We sought to determine… (More)
BACKGROUND
The effect of recent advances in critical care and the emphasis on early fracture fixation in patients with fat embolism syndrome (FES) are unknown.
OBJECTIVE
To better define FES in… (More)
Human survival from injury requires an appropriate inflammatory and immune response. We describe the circulating leukocyte transcriptome after severe trauma and burn injury, as well as in healthy… (More)
Proceedings of the National Academy of Sciences…
2013
A cornerstone of modern biomedical research is the use of mouse models to explore basic pathophysiological mechanisms, evaluate new therapeutic approaches, and make go or no-go decisions to carry new… (More)
OBJECTIVE
To identify patterns of errors contributing to inpatient trauma deaths.
METHODS
All inpatient trauma deaths at a high-volume level I trauma center from 1996 to 2004 inclusive were… (More)
OBJECTIVE
The detrimental effects of coagulopathy, hypothermia, and acidosis are well described as markers for mortality after traumatic hemorrhage. Recent military experience suggests that a high… (More)
OBJECTIVE
To determine the effectiveness of early, routine antioxidant supplementation using alpha-tocopherol and ascorbic acid in reducing the rate of pulmonary morbidity and organ dysfunction in… (More)
BACKGROUND
Blood transfusion is known to be an independent risk factor for mortality, multiple organ failure (MOF), acute respiratory distress syndrome (ARDS), and nosocomial infection after injury.… (More)
OBJECTIVE
To demonstrate whether daily bathing with cloths impregnated with 2% chlorhexidine gluconate will decrease colonization of resistant bacteria and reduce the rates of health care-associated… (More)