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PURPOSE Autologous, allogenic, and alloplastic materials for bony reconstruction in the craniomaxillofacial region have specific drawbacks stimulating the ongoing search for new materials. Cultivated skin and mucosa grafts are in clinical routine use in head and neck reconstruction but so far, to the best of our knowledge, no successful clinical application(More)
PURPOSE This article describes the use of tissue-engineered mucosal grafts instead of split-thickness skin grafts after freeing of the tongue in patients who had previous resection of an oral squamous cell carcinoma and initial primary wound closure. PATIENTS AND METHODS Tissue-engineered mucosal grafts, up to 75 cm2 in size, were cultured from biopsy(More)
Installation of fixtures for prosthetic reconstruction of the upper jaw in patients with extensive bone and soft tissue defects is still a challenge. The new fixture developed by Brånemark System achieves immediate prosthetic reconstruction by anchoring implants in the zygomatic bone to offer sufficient support without bone grafts. The dimension of these(More)
Autologous, allogenic and alloplastic materials for bony reconstruction in the cranio-maxillofacial area have many drawbacks thus stimulating the on-going search for new (bio-)materials. Whereas cultivated skin and mucosa are already in clinical routine use in head and neck reconstruction, so far there has been no successful clinical application to the best(More)
In 1984, Glassman et al. described a conservative surgical method of separation of the midpalatal suture in which an osteotomy is done only at the lateral and anterior wall of the maxilla. Between 1991 and 1997, we have operated on 21 patients with maxillary transverse discrepancies using the method that they described. This gave good results in 20(More)
BACKGROUND Tissue engineering of autogenous oral mucosa is a significant enrichment for various indications in oral and maxillofacial surgery. Besides preprosthetic surgery and prelamination of microvascular fasciocutaneous flaps, interdisciplinary work such as reconstruction procedures in cases of hypospadias and epispadias are the main indications for(More)
INTRODUCTION Angiogenesis is a cascade-like mechanism which is essential for tumour growth and metastasis. Therefore the existence of angiogenic molecules and the density of activated endothelial cells in individual tumours is of major interest. MATERIAL/PATIENTS: In order to evaluate the prognostic significance of these molecules, the distribution pattern(More)
PURPOSE To determine, as we did for paclit-axel, whether mitotic arrest and apoptosis induced in murine tumors in vivo by docetaxel correlate with the drug's antitumor effect and whether the antitumor efficacy of docetaxel depends on p53 mutational status of tumors. METHODS C3Hf/Kam mice were implanted with one of the following 15 syngeneic tumors: seven(More)
In urethra reconstruction, the creation of a new urethra from a free oral mucosa graft is an established surgical technique. The oral mucosa is removed at the same time that the urethra reconstruction procedure is performed. Depending on the size of graft required, the intraoral wound is closed primarily or left to heal secondarily. The latter method limits(More)
BACKGROUND Traumatic optic nerve lesions (TONL) are probable but unpredictable consequence after severe midface or skull base trauma. Based on a previously described rat model, the authors developed a new model in order to simulate optic nerve crush during trauma on the optic canal. METHODS To achieve a calibrated TONL, a microinjuring device was designed(More)