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A novel sensor kinase-response regulator hybrid controls biofilm formation and type VI secretion system activity in Burkholderia cenocepacia.

• Daniel F. Aubert, Ronald S. Flannagan, Miguel A Valvano
• Infection and immunity
• 2008

Burkholderia cenocepacia is an important opportunistic pathogen causing serious chronic infections in patients with cystic fibrosis (CF). Adaptation of B. cenocepacia to the CF airways may play an… (More)

Antimicrobial mechanisms of phagocytes and bacterial evasion strategies

• Ronald S. Flannagan, Gabriela Cosío, Sergio Grinstein
• Nature Reviews Microbiology
• 2009

Professional phagocytes have a vast and sophisticated arsenal of microbicidal features. They are capable of ingesting and destroying invading organisms, and can present microbial antigens on their… (More)

The cell biology of phagocytosis.

• Ronald S. Flannagan, Valentin Jaumouillé, Sergio Grinstein
• Annual review of pathology
• 2012

Engulfment and destruction of invading microorganisms by phagocytosis are critical components of the innate immune response. In addition, phagocytosis is also required for the clearance of apoptotic… (More)

A system for the construction of targeted unmarked gene deletions in the genus Burkholderia.

• Ronald S. Flannagan, Thomas Linn, Miguel A Valvano
• Environmental microbiology
• 2008

Burkholderia species are extremely multidrug resistant, environmental bacteria with extraordinary bioremediation and biocontrol properties. At the same time, these bacteria cause serious… (More)

A complete lipopolysaccharide inner core oligosaccharide is required for resistance of Burkholderia cenocepacia to antimicrobial peptides and bacterial survival in vivo.

• Slade A. Loutet, Ronald S. Flannagan, Cora Kooi, Pamela A. Sokol, Miguel A Valvano
• Journal of bacteriology
• 2006

Burkholderia cenocepacia is an important opportunistic pathogen of patients with cystic fibrosis. This bacterium is inherently resistant to a wide range of antimicrobial agents, including high… (More)

A putative gene cluster for aminoarabinose biosynthesis is essential for Burkholderia cenocepacia viability.

• Ximena P. Ortega, Silvia T Cardona, +5 authors Miguel A Valvano
• Journal of bacteriology
• 2007

Using a conditional mutagenesis strategy we demonstrate here that a gene cluster encoding putative aminoarabinose (Ara4N) biosynthesis enzymes is essential for the viability of Burkholderia… (More)

Burkholderia cenocepacia requires a periplasmic HtrA protease for growth under thermal and osmotic stress and for survival in vivo.

• Ronald S. Flannagan, Daniel Aubert, Cora Kooi, Pamela A. Sokol, Miguel A Valvano
• Infection and immunity
• 2007

Burkholderia cenocepacia, a member of the B. cepacia complex, is an opportunistic pathogen that causes serious infections in patients with cystic fibrosis. We identified a six-gene cluster in… (More)

Assessment of three Resistance-Nodulation-Cell Division drug efflux transporters of Burkholderia cenocepacia in intrinsic antibiotic resistance

• Silvia Buroni, Maria Rosalia Pasca, +6 authors Giovanna Riccardi
• BMC Microbiology
• 2009

Burkholderia cenocepacia are opportunistic Gram-negative bacteria that can cause chronic pulmonary infections in patients with cystic fibrosis. These bacteria demonstrate a high-level of intrinsic… (More)

Lysosomal calcium homeostasis defects, not proton pump defects, cause endo-lysosomal dysfunction in PSEN-deficient cells

• Katrijn Coen, Ronald S. Flannagan, +11 authors Wim Annaert
• The Journal of cell biology
• 2012

Presenilin (PSEN) deficiency is accompanied by accumulation of endosomes and autophagosomes, likely caused by impaired endo-lysosomal fusion. Recently, Lee et al. (2010. Cell. doi:… (More)

Dynamic macrophage “probing” is required for the efficient capture of phagocytic targets

• Ronald S. Flannagan, Rene E. Harrison, Christopher M Yip, Khuloud Jaqaman, Sergio Grinstein
• The Journal of cell biology
• 2010

Binding of ligands by immunoreceptors is thought to be a passive, stochastic process. Contrary to this notion, we found that binding of IgG-opsonized particles by Fcγ receptors was inhibited in… (More)

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