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Genome-wide identification of the mechanism of action (MoA) of small-molecule compounds characterizing their targets, effectors, and activity modulators represents a highly relevant yet elusive goal, with critical implications for assessment of compound efficacy and toxicity. Current approaches are labor intensive and mostly limited to elucidating(More)
A central challenge in designing and administering effective anticoagulants is achieving the proper therapeutic window and dosage for each patient. The Hill coefficient, nH, which measures the steepness of a dose-response relationship, may be a useful gauge of this therapeutic window. We sought to measure the Hill coefficient of available anticoagulants to(More)
Discoveries of exons that correctly code for a gene are crucial in predicting protein sequences and determining protein function. This can be accomplished using one of two methods: through computational tools or through experimental laboratory techniques. Regardless of how these exon coding regions are derived, they need to be properly annotated before they(More)
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