Ronald Q. Smith

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Protein analysis (using either specific protein quantitation by methods such as HPLC and immunoassays or structural analysis by methods such as LC-MS) usually requires significant sample preparation, including quantitative purification of the target protein from complex sample matrices and potentially enzymatic treatment or labeling. We have developed(More)
Reported associations between air pollution and pulmonary and cardiovascular diseases prompted studies on the effects of gold nanoparticles (Au NP) on pulmonary surfactant function. Low levels (3.7 mol % Au/lipid, 0.98% wt/wt) markedly inhibited adsorption of a semisynthetic pulmonary surfactant (dipalmitoyl-phosphatidylcholine(More)
For the non-constant coefficient advection-diffusion equation with decay a(∂ t c + λ c + u ∂ s c) − ∂ s (a κ ∂ s c) = q , the non-uniformity can almost be removed with a local change of variables from c(s, t) to b(x, t). So, in numerical computations non-uniformity need not imply any reduction from optimal accuracy. A computational grid that was uniformly(More)
PURPOSE To report the short-term outcome of gamma-irradiated sterile cornea in corneal and glaucoma patch graft surgeries when viable endothelium is not necessary. METHODS Surgeons who have used the irradiated corneas were asked to rate their impression from 1 (fair) to 4 (very good). Specific intraoperative questions included availability, ease of use,(More)
An implicit finite difference scheme is derived which achieves exact results for the area, centroid, variance, skewness and kurtosis (flatness) of solutions to the unforced advection-diffusion equation ∂ t c + λ c + u ∂ x c − κ ∂ 2 x c = 0. Sufficient conditions for computational stability are that the grid spacing ∆x and time step ∆t be small enough that(More)
Developing new antiretroviral therapies for HIV-1 infection with potential for less frequent dosing represents an important goal within drug discovery. Herein, we present the discovery of ethyl (1-((4-((4-fluorobenzyl)carbamoyl)-1-methyl-2-(2-(5-methyl- 1,3,4-oxadiazole-2-carboxamido)propan-2-yl)-6-oxo-1,6-dihydropyrimidin-5-yl)oxy)ethyl) carbonate(More)