Ronald P Beaney

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The cerebral pH of four normal human subjects has been measured using continuous inhalation of 11CO2 and positron emission tomography (PET). 11CO2 was administered to each subject at a constant rate for 15 min, during which time serial arterial plasma 11C levels were determined and serial 11C cerebral uptake PET scans were performed at a fixed axial(More)
Regional blood flow, oxygen extraction ratio, and oxygen utilisation were measured in nine patients with breast carcinoma by means of the oxygen-15 steady-state inhalation technique and positron emission tomography. Regional blood volume was measured by means of tracer amounts of carbon-11-labelled carbon monoxide. The regional blood flow was consistently(More)
Regional values for cerebral blood flow, blood volume, oxygen extraction fraction, and oxygen utilization were measured, using PET, in 10 brain tumor patients before and after treatment with dexamethasone. Dexamethasone treatment decreased cerebral blood flow and blood volume and increased the fractional extraction of oxygen throughout the brain without(More)
Using positron emission tomography, regional cerebral blood flow and oxygen utilisation were measured in the contralateral cortex of 14 patients with a variety of intracranial tumours. A comparison was made with cortical values derived from 14 normal controls. Compared with normal subjects, patients with brain tumours had a significant reduction in oxygen(More)
This study was undertaken to confirm the belief that modern day external beam radiotherapy for patients with pituitary tumours should not be associated with any ischaemic temporal lobe damage. Using the oxygen-15 steady state inhalation technique and positron emission tomography regional temporal lobe blood flow, oxygen extraction fraction and oxygen(More)
Using PET, we measured regional cerebral oxygen utilization, oxygen extraction, blood flow, and blood volume in five patients with benign intracranial hypertension. No significant differences in regional cerebral function were found between the patients and 15 age-matched normal controls. Cerebral decompression with a lumboperitoneal shunt produced little(More)
The treatment of recurrent malignant glioma is difficult and at present largely disappointing. Furthermore the results of any treatment modality need to be interpreted with knowledge regarding patient selection and timing of treatment. The results of interstitial brachytherapy using iodine-125 in 23 patients are presented. There were no operative(More)
Interstitial brachytherapy for recurrent gliomas normally necessitates the invasive application of a stereotactic frame by screw-fixation which must be kept on for several hours. The use of a relocatable stereotactic frame offers many advantages over conventional systems. We present our experience in 18 patients and verify that the frame used is accurate,(More)
The BRAF V600E mutation has recently been identified in a high percentage of papillary craniopharyngiomas [1, 2]. The V600E mutation constitutively activates the MEK-ERK pathway, and the mutation-specific BRAF inhibitor vemurafenib, which targets mutated BRAF, is effective in malignant melanoma [3]. The use of vemurafenib in malignancy now includes hairy(More)