Learn More
Aberrant PI3K/Akt signaling has been implicated in many human cancers, including prostate carcinomas. Currently different therapeutic strategies target the inhibition of this survival pathway. The nucleoside analog triciribine (TCN), which was initially described as a DNA synthesis inhibitor, has recently been shown to function as an inhibitor of Akt. Here,(More)
A variety of nucleoside analogs have shown carcinostatic activity. In some instances they are relatively rapidly excreted. In others they are relatively rapidly inactivated in vivo by catabolic enzymes. In both cases it appeared desirable to have nucleoside derivatives that would act as depot forms of the nucleoside analogs and would be converted in vivo to(More)
The taxonomy of thePenicillium camemberti andP. roqueforti series is re-investigated.P. caseicolum Bainier is regarded as a synonym ofP. camemberti Thom on the basis of morphological characters.P. casei Staub is considered to be identical withP. verrucosum Dierckx var.cyclopium (Westling) Samson, Stolk et Hadlok. Descriptions and illustrations ofP.(More)
Vancomycin is a potent glycopeptide antibiotic that has evolved to specifically bind to the D-Ala-D-Ala dipeptide termini of nascent peptidoglycans. Although this mode of action is well established, several studies indicate that vancomycin and analogues exploit noncanonical target sites. In order to address all vancomycin targets in clinically relevant(More)
Selective release of enriched biomolecules from solid support is a desirable goal in proteomic and metabolomic studies. Here we demonstrate that photocleavage of a light-sensitive phenacyl ester bond is a suitable alternative cleavage strategy for the selective release of enriched biomolecules form avidin beads circumventing the disadvantages of(More)