Ronald M. Iorio

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Measles virus (MeV), a member of the paramyxovirus family of enveloped RNA viruses and one of the most infectious viral pathogens identified, accounts for major pediatric morbidity and mortality worldwide although coordinated efforts to achieve global measles control are in place. Target cell entry is mediated by two viral envelope glycoproteins, the(More)
Transglutaminases (E.C. 2.3.2.13) catalyze the post-translational modification of proteins by establishing ε-(γ-glutamyl) lysine isopeptide bonds and by the covalent conjugation of polyamines to endo-glutamyl residues of proteins. In light of the confirmed role of transglutaminases in animal cell apoptosis and only limited information on the role of these(More)
The promotion of membrane fusion by Newcastle disease virus (NDV) requires an interaction between the viral hemagglutinin-neuraminidase (HN) and fusion (F) proteins, although the mechanism by which this interaction regulates fusion is not clear. The NDV HN protein exists as a tetramer composed of a pair of dimers. Based on X-ray crystallographic studies of(More)
Membrane fusion is essential for entry of the biomedically-important paramyxoviruses into their host cells (viral-cell fusion), and for syncytia formation (cell-cell fusion), often induced by paramyxoviral infections [e.g. those of the deadly Nipah virus (NiV)]. For most paramyxoviruses, membrane fusion requires two viral glycoproteins. Upon receptor(More)
The promotion of membrane fusion by most paramyxoviruses requires an interaction between the viral attachment and fusion (F) proteins to enable receptor binding by the former to trigger the activation of the latter for fusion. Numerous studies demonstrate that the F-interactive sites on the Newcastle disease virus (NDV) hemagglutinin-neuraminidase (HN) and(More)
  • Ritu Rakshit, Bradley, Ritu Bradley, Rakshit, Rakshit Ritu, Bradley +10 others
  • 2015
Pars of this dissertation have been presented in the following publication: Title: Vaccinia virus KIL protein mediates host-range fuction in RK-13 cells via anyrin repeat and may interact with a cellular GTPase-activating protein. allowing me the opportity to grow through this very enlightening experience. I would like to than the Center for Infectious(More)
ACKNOWLEDGMENTS First of all, I would like to thank my dissertation advisor, Dr. Chrstie Holland for her support, advice and encouragement. I would also like to thank Drs. Nancy DiFronzo Anamaris M. Colberg-Poley, Cynthia Pise and Patrcio Ray for sharing their knowledge and guidance. I would like to especially thank Dr. Terrence Flotte whose support and(More)
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