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PURPOSE To test the hypothesis that early rod dysfunction predicts the blood vessel abnormalities that are the clinical hallmark of retinopathy of prematurity (ROP). METHODS Two rat models of ROP, induced by exposure to alternating 50%/10% oxygen (50/10 model) from postnatal day (P) 0 to P14, or exposure to 75% oxygen (75 model) from P7 to P14, and(More)
PURPOSE To study electroretinographic a- and b-wave responses of rats at the ages during which rod outer segment length (ROS) and rhodopsin content increase. METHODS Electroretinographic responses to brief, full-field stimuli were recorded from dark-adapted young (ages 12 to 30 days) and adult rats. The amplitude of the a-wave and the amplitude and(More)
PURPOSE To study electroretinographic responses of infant rats with a history of exposure to high-ambient oxygen. METHODS Electroretinographic responses to a range of full-field stimuli were recorded from 13-day-old (n = 8) and 18-day-old (n = 10) rats with a history of intermittent exposure to 80% oxygen and age-matched controls. The a-waves were fitted(More)
PURPOSE In a rat model of retinopathy of prematurity (ROP), the retinal vasculature and function of the neural retina were studied longitudinally. Vascular and neural parameters were evaluated for significant relationships. METHODS Retinopathy was induced by exposing newborn rats to alternating 50% and 10% oxygen until age 14 days. To evaluate the(More)
UNLABELLED PURPOSE. Test the hypothesis that the developmental increases in rod photoreceptor sensitivity and rod-mediated visual sensitivity at 10 degrees, 20 degrees , and 30 degrees eccentric are concurrent. It is known that maturation of the parafoveal (10 degrees eccentric) rod outer segments and visual sensitivity is delayed compared to that at 30(More)
PURPOSE To study the development of the electroretinographic (ERG) oscillatory potentials (OPs) in two rat models of ROP and in human subjects with a history of ROP. METHODS Sprague-Dawley rats (n = 36) were studied longitudinally. Rat models of ROP were induced, either by exposure to alternating 50%/10% oxygen (50/10 model) from postnatal day (P) 0 to(More)