Ronald Laufer

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Future computing workloads will emphasize an architecture's ability to perform relatively simple calculations on massive quantities of mixed-width data. This paper describes a novel reconfigurable fabric architecture, PipeRench, optimized to accelerate these types of computations. PipeRench enables fast, robust compilers, supports forward compatibility, and(More)
Reconfigurable hardware accelerators have been shown to be flexible and efficient in stream-based applications. In this paper, we discuss the design of PCI-PipeRench and the SWORDAPI. PCI-PipeRench is a coprocessor utilizing the PipeRench architecture which includes on-chip control and data buffering to interface with a host processor over a PCI bus.(More)
In both the central and the peripheral nervous systems, impulse activity regulates the expression of a vast number of genes that code for synaptic proteins, including neuropeptides, enzymes involved in neurotransmitter biosynthesis and degradation, and membrane receptors. In recent years, the mechanisms involved in these regulations became amenable to(More)
Using primary cultures of chicken myotubes, we investigated the involvement of protein kinase C and Ca2+ in the repression of nicotinic acetylcholine receptor (AChR) biosynthesis by electrical activity. Treatment with the Ca2+ channel blocker verapamil or the Na+ channel blocker tetrodotoxin increased alpha subunit mRNA levels 11.5- to 15-fold. The effect(More)
Recent immunocytochemical studies have shown that calcitonin gene-related peptide (CGRP) coexists with the neurotransmitter acetylcholine in spinal motoneurons of the chick. Moreover, CGRP causes an increase in the number of acetylcholine receptors on the surface of cultured chick myotubes. CGRP might thus serve as one of the signals by which motoneurons(More)
The Calcitonin-Gene Related Peptide (CGRP), a neuropeptide present in chick spinal cord motoneurons, increases the levels of surface acetylcholine receptor (AChR) and of the AChR alpha-subunit mRNA in cultured chick myotubes. Cholera toxin (CT), an activator of adenylate cyclase, produces a similar effect which does not add up with that of CGRP. Consistent(More)
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