Ronald Jäger

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Pigeons with lesions of the lateral part of the telencephalon, visual Wulst, and fronto-archistriatal tract were compared with sham-operated controls in 2 procedures. In one of them the time it took the pigeons to grasp and eat a certain number of grains was recorded. In the other experiment the number of grains was counted that the pigeons consumed out of(More)
Pigeons were trained to preferentially peck the centermost element of a concentric key array. When they had learned the task to a criterion the subjects received lesions of the lateral telencephalon. The ablation caused an unexpected performance improvement, proportionally more pecks being directed at the central key element. However, on closer analysis(More)
The contribution of forebrain structures to the control of visually guided eating behaviors was studied using a technique for reversible 'visual decerebration'. The procedure is based upon the fact that structures in the thalamus and telencephalon receive their visual inputs primarily from the contralateral eye. When the eye contralateral to the ablated(More)
Since the discovery of two parallel visual systems in humans and primates there has been much speculation about their functions. One prominent current model, suggesting independent processing of visual information for perception and action, is supported by neuroanatomical, electrophysiological, neurobehavioral, and human clinical data. Furthermore, studies(More)
Nitric oxide (NO) acts as essential regulator of vasculogenesis and angiogenesis and is critical for arteriogenesis. Whether NO’s effects in vivo are mediated through NO-sensitive guanylyl cyclase (NO-GC) and thus by cGMP-dependent mechanisms has been only poorly addressed. Mice lacking NO-GC globally or specifically in smooth muscle cells (SMC) or(More)
NO-sensitive guanylyl cyclase (NO-GC) is accepted to be the major receptor for the signaling molecule NO. Deletion of NO-GC in mice leads to disturbed NO/cGMP signaling. As a result, these mice show abolished NO-dependent relaxation of smooth muscle-containing tissues in the cardiovascular and gastrointestinal systems. Mice with general deletion suffer from(More)
Phosphodiesterases (PDE) are considered to be key players in many signal transduction pathways. They degrade the second messengers cGMP and cAMP, thereby controlling their intracellular levels. So far, eleven PDE families, typically having several isoforms and splice variants are known. The PDE10 family is encoded by one gene that gives rise to at least two(More)