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PURPOSE To study electroretinographic a- and b-wave responses of rats at the ages during which rod outer segment length (ROS) and rhodopsin content increase. METHODS Electroretinographic responses to brief, full-field stimuli were recorded from dark-adapted young (ages 12 to 30 days) and adult rats. The amplitude of the a-wave and the amplitude and(More)
The ocular media densities of eleven 10-week-old infants and of 10 adults were estimated from dark adapted thresholds measured using a two alternative forced choice preferential looking method. The estimated media density at 400 nm derived from these thresholds ranged from 0.55 to 1.00 (median 0.75) log units for infants, and from 1.35 to 1.69 (median 1.46)(More)
Two-dimensional eye movements were recorded while subjects used a hammer to strike targets that were flashed-on briefly before, during or up to 750 msec after a horizontal saccade. Mean position of hammer blows was 20 min arc (SD = 67 min arc) from the target when the only cue to target location was eye position. Position of responses varied slightly with(More)
PURPOSE To study the development of the electroretinographic (ERG) oscillatory potentials (OPs) in two rat models of ROP and in human subjects with a history of ROP. METHODS Sprague-Dawley rats (n = 36) were studied longitudinally. Rat models of ROP were induced, either by exposure to alternating 50%/10% oxygen (50/10 model) from postnatal day (P) 0 to(More)
PURPOSE To test the hypothesis that early rod dysfunction predicts the blood vessel abnormalities that are the clinical hallmark of retinopathy of prematurity (ROP). METHODS Two rat models of ROP, induced by exposure to alternating 50%/10% oxygen (50/10 model) from postnatal day (P) 0 to P14, or exposure to 75% oxygen (75 model) from P7 to P14, and(More)
PURPOSE Longitudinal studies in rat models of retinopathy of prematurity (ROP) have demonstrated that abnormalities of retinal vasculature and function change hand-in-hand. In the developing retina, vascular and neural structures are under cooperative molecular control. In this study of rats with oxygen-induced retinopathy (OIR) models of ROP, mRNA(More)