Ronald A. J. van Elburg

Learn More
Rapid calcium concentration changes in postsynaptic structures are crucial for synaptic plasticity. Thus far, the determinants of postsynaptic calcium dynamics have been studied predominantly based on the decay kinetics of calcium transients. Calcium rise times in spines in response to single action potentials (AP) are almost never measured due to technical(More)
Neurons display a wide range of intrinsic firing patterns. A particularly relevant pattern for neuronal signaling and synaptic plasticity is burst firing, the generation of clusters of action potentials with short interspike intervals. Besides ion-channel composition, dendritic morphology appears to be an important factor modulating firing pattern. However,(More)
Electrical oscillations in neuronal network activity are ubiquitous in the brain and have been associated with cognition and behavior. Intriguingly, the amplitude of ongoing oscillations, such as measured in EEG recordings, fluctuates irregularly, with episodes of high amplitude alternating with episodes of low amplitude. Despite the widespread occurrence(More)
Extended Abstract The evolution of the earliest nervous systems remains seriously under-researched. Within this small field, the focus has recently mostly been on the evolution of the first nerve cells, early nervous system centralization and biomolecular precursors of nerve cells and their components (Lichtneckert & Reichert, 2007). Another relevant line(More)
An event-based integration scheme for an integrate-and-fire neuron model with exponentially decaying excitatory synaptic currents and double exponential inhibitory synaptic currents has been introduced by Carnevale and Hines. However, the integration scheme imposes nonphysiological constraints on the time constants of the synaptic currents, which hamper its(More)
How and why the first nervous systems evolved remain open questions. One influential scenario casts excitable myoepithelia (epithelia that combine conductive and contractile properties) as a plausible proto-nervous system. We argue that while modern myoepithelia rely on gap junctions, early myoepithelia had to rely on paracrine signalling or equivalently(More)
Internal coordination models hold that early nervous systems evolved in the first place to coordinate internal activity at a multicellular level, most notably the use of multicellular contractility as an effector for motility. A recent example of such a model, the skin brain thesis, suggests that excitable epithelia using chemical signaling are a potential(More)
In this paper we introduce a continuous time stochastic neurite branching model closely related to the discrete time stochastic BES-model. The discrete time BES-model is underlying current attempts to simulate cortical development, but is difficult to analyze. The new continuous time formulation facilitates analytical treatment thus allowing us to examine(More)
Psycho-acoustical research investigates how human listeners are able to separate sounds that stem from different sources. This ability might be one of the reasons that human speech processing is robust to noise but methods that exploit this are, to our knowledge, not used in systems for automatic formant extraction or in modern speech recognition systems.(More)
  • 1