Ron Wever

Learn More
N itric oxide is a principal factor involved in the antiathero-sclerotic properties of the endothelium. 1–3 NO interferes in vitro with key events in the development of atherosclerosis, such as monocyte and leukocyte adhesion to the endotheli-um 4–7 as well as platelet–vessel wall interaction. 8 –10 NO also decreases endothelial permeability and reduces(More)
BACKGROUND Impaired nitric oxide (NO) activity is an early event in the pathogenesis of cardiovascular disease, resulting from either reduced NO formation or increased NO degradation. Administration of tetrahydrobiopterin (BH4), an essential cofactor for NO production, could restore NO activity in familial hypercholesterolemia (FH). Because folates have(More)
In patients with chronic renal failure (CRF), atherosclerosis is a major cause of cardiovascular morbidity and mortality. Generally, atherosclerosis has been associated with a reduced bioavailability of nitric oxide (NO). Experimental studies have indicated the presence of enhanced NO degradation by reactive oxygen species as well as decreased NO production(More)
Triglyceride-rich lipoproteins that circulate postprandially are increasingly being recognized as potentially atherogenic. These particles also have been shown to cause endothelial dysfunction. We recently demonstrated that acute parenteral administration of folic acid restores endothelial function in vivo in patients with increased LDL cholesterol levels.(More)
Vanadium haloperoxidases differ strongly from heme peroxidases in substrate specificity and stability and in contrast to a heme group they contain the bare metal oxide vanadate as a prosthetic group. These enzymes specifically oxidize halides in the presence of hydrogen peroxide into hypohalous acids. These reactive halogen intermediates will react rapidly(More)
Cascade synthetic pathways, which allow multi-step conversions to take place in one reaction vessel, are crucial for the development of biomimetic, highly efficient new methods of chemical synthesis. Theoretically, the complexity introduced by combining processes could lead to an improvement of the overall process; however, it is the current general belief(More)
A set of phosphatases was evaluated for their potential to catalyze the regio-and stereoselective phosphorylation of alcohols using a high-energy inorganic phosphate donor, such as di-, tri-and polyphosphate. Parameters such as type and amount of phosphate donor and pH of the reaction were investigated in order to minimize the thermodynamically favored(More)
The human circadian system controlling the variety of overt 24-h rhythms consists of some different oscillators which are separately self-sustained. Normally, all oscillators run synchronously to each other; under certain external and internal conditions (e.g. increasing score of neuroticism, or old age), however, they run in the steady state with different(More)
  • 1