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Moral hazard is one of the most basic concepts in economics: If someone pays you for your accidents, you will expend less effort trying to avoid them. Insurance companies understand this perfectly well. That's why most insurance contracts include customer deductibles and limited coverage. This seems straightforward enough. Why is it, then, that policymakers(More)
Ets transcription factors control multiple biological processes, including cell proliferation, differentiation, apoptosis, angiogenesis, transformation , and invasion. Pdef is an Ets transcription factor originally identified in prostate tissue. We demonstrate that human Pdef is expressed at high levels primarily in tissues with high epithelial cell(More)
Hyaluronan (HA) is an abundant matrix molecule, the function of which in the skin remains to be fully defined. To explore the roles of HA in cutaneous injury responses, double-knockout mice (abbreviated as Has1/3 null) that lack two HA synthase enzymes (Has1 and Has3), but still express functional Has2, were used in two types of experiments: (i) application(More)
Acute SLE courses with antibody-secreting cells (ASC) surges whose origin, diversity, and contribution to serum autoantibodies remain unknown. Deep sequencing, autoantibody proteome and single-cell analysis demonstrated highly diversified ASC punctuated by V H 4-34 clones that produce dominant serum autoantibodies. A fraction of ASC clones contained(More)
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