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Ets transcription factors control multiple biological processes, including cell proliferation, differentiation, apoptosis, angiogenesis, transformation , and invasion. Pdef is an Ets transcription factor originally identified in prostate tissue. We demonstrate that human Pdef is expressed at high levels primarily in tissues with high epithelial cell(More)
Hyaluronan (HA) is an abundant matrix molecule, the function of which in the skin remains to be fully defined. To explore the roles of HA in cutaneous injury responses, double-knockout mice (abbreviated as Has1/3 null) that lack two HA synthase enzymes (Has1 and Has3), but still express functional Has2, were used in two types of experiments: (i) application(More)
T hree government-sponsored enterprises (GSEs) play a central role in U.S. housing finance markets. Together, the Federal National Mortgage Association (Fannie Mae), the Federal Home Loan Mortgage Corporation (Freddie Mac), and the Federal Home Loan Bank System (FHLB System) hold or insure nearly $3 trillion in primarily mortgage-related assets. The three(More)
Acute SLE courses with antibody-secreting cells (ASC) surges whose origin, diversity, and contribution to serum autoantibodies remain unknown. Deep sequencing, autoantibody proteome and single-cell analysis demonstrated highly diversified ASC punctuated by V H 4-34 clones that produce dominant serum autoantibodies. A fraction of ASC clones contained(More)
Chicago for valuable comments and suggestions. The views expressed herein are those of the authors and not necessarily those of the Federal Reserve Bank of Chicago, the Federal Reserve Bank of Minneapolis, or the Federal Reserve System. Abstract Congress mandated that the Federal Reserve System ensure that commercial banks meet the credit needs of their(More)