Romulo Ribeiro

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Monitoring of the plasmatic levels of levodopa (LEV) and carbidopa (CAR) is necessary to adjust the dose of these drugs according to the individual needs of Parkinson's disease patients. To support drug therapeutic monitoring, a method using HILIC mode and LC-MS/MS was developed for the simultaneous determination of carbidopa, levodopa, and its metabolites(More)
This paper discusses the use of the Policy Based Network paradigm, COPS (Common Open Policy Service) and NSIS (Next Steps In Signalling) frameworks being developed by the IETF, in the context of the European Project EuQoS (End-to-End Quality of Service over Heterogeneous Networks). An overview of the EuQoS architecture is provided followed by the analysis(More)
The objective of this work was to develop and validate a HILIC-MS/MS method for the simultaneous determination of metformin and vildagliptin in human plasma. Chromatographic separation was achieved using an Atlantis HILIC Silica 150-mm × 2.1-mm, 3-μm particle size column maintained at 40°C. The isocratic mobile phase consisted of 20% water and 80%(More)
In this talk I will provide an overview of Computational Argumentation, focusing on two wellknown and widely used approaches, namely abstract argumentation and assumption-based argumentation, and their possible uses in Web contexts, and in particular the Semantic Web and Social Networks. For both forms of Computational Argumentation, I will outline(More)
BACKGROUND In this study, we developed and validated a HPLC-MS/MS method capable of simultaneously determining levodopa, carbidopa, entacapone, tolcapone, 3-O-methyldopa and dopamine in human plasma. RESULTS & METHODOLOGY: Chromatographic separation was achieved using a C8 column with a mobile phase consisting of a gradient of water and(More)
Malva sylvestris, popularly known as “malva” in Brazil, is a medicinal plant used for its antiinflammatory effects. However, multiple plants are known as “malvas” in Brazil; these species include Sida cordifolia (“malva-branca”) and Pelargonium graveolens (“malva-cheirosa”). In this work, electrospray mass spectrometry metabolic fingerprints from these(More)
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