oxicity of the synthetic polymeric 3-alkylpyridinium salt ( APS 3 ) is due to pecific block of nicotinic acetylcholine receptors
- arjana Grandič, Romulo Aráozb, obert Frangeža
- Biology, Chemistry
In vitro experiments confirmed the inhibitory effect of APS3 on mouse hemidiaphragm nerve-evoked muscle contraction with a median inhibitory concentration (IC50) of 20.3 M, without affecting directly elicited muscle contraction.
A blocks Torpedo nicotinic acetylcholine receptors
- lara Bulc Rozmana, Romulo Aráozb, K. Sepčič, Jordi Molgób, Dušan Šuputa
Parazoanthoxanthin A dose-dependently reduced the acetylcholine-induced currents and reduced the Hill coefficient and the time to peak current, indicating a channel blocking mode of action.