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Mammalian sleep varies widely, ranging from frequent napping in rodents to consolidated blocks in primates and unihemispheric sleep in cetaceans. In humans, rats, mice and cats, sleep patterns are orchestrated by homeostatic and circadian drives to the sleep-wake switch, but it is not known whether this system is ubiquitous among mammals. Here, changes of(More)
The effects of permanent shift work on entrainment and sleepiness are examined using a mathematical model that combines a model of sleep-wake switch in the brain with a model of the human circadian pacemaker entrained by light and nonphotic inputs. The model is applied to 8-hour permanent shift schedules to understand the basic mechanisms underlying changes(More)
Unihemispheric sleep has been observed in numerous species, including birds and aquatic mammals. While knowledge of its functional role has been improved in recent years, the physiological mechanisms that generate this behavior remain poorly understood. Here, unihemispheric sleep is simulated using a physiologically based quantitative model of the mammalian(More)
This paper examines nonlinear effects in a neural field model of the corticothalamic system to predict the EEG power spectrum of sleep spindles. Nonlinearity in the thalamic relay nuclei gives rise to a spindle harmonic visible in the cortical EEG. By deriving an analytic expression for nonlinear spectrum, the power in the spindle harmonic is predicted to(More)
OBJECTIVE To investigate the properties of a sleep spindle harmonic oscillation previously predicted by a theoretical neural field model of the brain. METHODS Spindle oscillations were extracted from EEG data from nine subjects using an automated algorithm. The power and frequency of the spindle oscillation and the harmonic oscillation were compared(More)
We introduce a new problem, the Online Selective Anomaly Detection (OSAD), to model a specific scenario emerging from research in sleep science. Scientists have segmented sleep into several stages and stage two is characterized by two patterns (or anomalies) in the EEG time series recorded on sleep subjects. These two patterns are sleep spindle (SS) and(More)
A real-time fitting system is developed and used to fit the predictions of an established physiologically-based neural field model to electroencephalographic spectra, yielding a trajectory in a physiological parameter space that parametrizes intracortical, intrathalamic, and corticothalamic feedbacks as the arousal state evolves continuously over time. This(More)
A1 Functional advantages of cell-type heterogeneity in neural circuits Tatyana O. Sharpee A2 Mesoscopic modeling of propagating waves in visual cortex Alain Destexhe A3 Dynamics and biomarkers of mental disorders Mitsuo Kawato F1 Precise recruitment of spiking output at theta frequencies requires dendritic h-channels in multi-compartment models of(More)
A neural field model of the brain is used to represent brain states using physiologically based parameters rather than arbitrary, discrete sleep stages. Each brain state is represented as a point in a physiologically parametrized space. Over time, changes in brain state cause these points to trace continuous trajectories, unlike the artificial discrete(More)
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