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  • Francesco Piscitelli, Antonio Coluccia, +12 authors Romano Silvestri
  • Chemistry, Medicine
  • Journal of medicinal chemistry
  • 2009 (First Published: 9 April 2009)
  • New potent indolylarylsulfone (IAS) HIV-1 NNRTIs were obtained by coupling natural and unnatural amino acids to the 2-carboxamide and introducing different electron-withdrawing substituents atContinue Reading
  • Giuseppe La Regina, Taradas Sarkar, +19 authors Romano Silvestri
  • Chemistry, Medicine
  • Journal of medicinal chemistry
  • 2009 (First Published: 10 December 2009)
  • New arylthioindoles along with the corresponding ketone and methylene compounds were potent tubulin assembly inhibitors. As growth inhibitors of MCF-7 cells, sulfur derivatives were superior orContinue Reading
  • Giuseppe La Regina, Ruoli Bai, +21 authors Romano Silvestri
  • Chemistry, Medicine
  • Journal of medicinal chemistry
  • 2011 (First Published: 22 December 2011)
  • New arylthioindoles (ATIs) were obtained by replacing the 2-alkoxycarbonyl group with a bioisosteric 5-membered heterocycle nucleus. The new ATIs 5, 8, and 10 inhibited tubulin polymerization,Continue Reading
  • Vincenzo Giansanti, Tania Camboni, +6 authors Anna I. Scovassi
  • Biology, Medicine
  • The international journal of biochemistry & cell…
  • 2009 (First Published: 1 October 2009)
  • Drug resistance of cancer cells is often correlated with the evasion of apoptosis, thus a major goal in cancer research is to search for compounds able to counteract cancer by promoting apoptosis. AContinue Reading
  • Giuseppe La Regina, Ruoli Bai, +29 authors Romano Silvestri
  • Chemistry, Medicine
  • Journal of medicinal chemistry
  • 2013 (First Published: 10 January 2013)
  • New arylthioindole derivatives having different cyclic substituents at position 2 of the indole were synthesized as anticancer agents. Several compounds inhibited tubulin polymerization atContinue Reading
  • Giuseppe La Regina, Antonio Coluccia, +12 authors Romano Silvestri
  • Chemistry, Medicine
  • Journal of medicinal chemistry
  • 2015 (First Published: 12 November 2015)
  • New 1,1'-biphenylsulfonamides were synthesized and evaluated as inhibitors of the ubiquitous human carbonic anhydrase isoforms I, II, IX, XII, and XIV using acetazolamide (AAZ) as reference compound.Continue Reading
  • Valeria Famiglini, Giuseppe La Regina, +10 authors Romano Silvestri
  • Chemistry, Medicine
  • European journal of medicinal chemistry
  • 2014 (First Published: 1 June 2014)
  • New indolylarylsulfone HIV-1 NNRTIs were synthesized to evaluate unexplored substitutions of the benzyl/phenylethyl group linked at the indole-2-carboxamide. Against the NL4-3 HIV-1 WT strain, 17 outContinue Reading
  • Laura Masuelli, Fabrizio Pantanella, +10 authors Roberto Bei
  • Biology, Medicine
  • Tumor Biology
  • 2015 (First Published: 1 March 2016)
  • Violacein (VIO; 3-[1,2-dihydro-5-(5-hydroxy-1H-indol-3-yl)-2-oxo-3H-pyrrol-3-ylidene]-1,3-dihydro-2H-indol-2-one), an indole-derived purple-colored pigment, produced by a limited number ofContinue Reading